Analysis of Anti-Glycan IgG and IgM Antibodies in Colorectal Cancer


如何引用文章

全文:

开放存取 开放存取
受限制的访问 ##reader.subscriptionAccessGranted##
受限制的访问 订阅存取

详细

We propose an approach that allows simultaneous determination of the levels of M and G isotypes of antibodies to the panel of glycans using microarrays. The level of IgG antibodies to 3’-O-su-Lea glycan detects patients with colorectal cancer with a sensitivity of 69.77% and specificity of 62.75%. The percentage of correctly classified colorectal cancer patients with the use of a combination of two markers IgM antibodies to glycans 3’-sialyl-TF and 3’-O-su-Lea is as high as 74.23%. The levels of IgM antibodies to 3’-O-su-Lea glycan differ significantly in patients with and without regional metastases. The levels of some of antiglycan IgM or IgG antibodies differed significantly in patients with tumors of different location and differentiation.

作者简介

A. Tikhonov

V. A. Engelhardt Institute of Molecular Biology, Russian Academy of Sciences

编辑信件的主要联系方式.
Email: alex.tihonoff@gmail.com
俄罗斯联邦, Moscow

E. Savvateeva

V. A. Engelhardt Institute of Molecular Biology, Russian Academy of Sciences

Email: alex.tihonoff@gmail.com
俄罗斯联邦, Moscow

M. Chernichenko

P. A. Hertsen Moscow Research Oncological Institute, Affiliated Branch of National Medical Research Center of Radiology, Ministry of Health of the Russian Federation

Email: alex.tihonoff@gmail.com
俄罗斯联邦, Moscow

V. Maslennikov

V. A. Engelhardt Institute of Molecular Biology, Russian Academy of Sciences

Email: alex.tihonoff@gmail.com
俄罗斯联邦, Moscow

D. Sidorov

P. A. Hertsen Moscow Research Oncological Institute, Affiliated Branch of National Medical Research Center of Radiology, Ministry of Health of the Russian Federation

Email: alex.tihonoff@gmail.com
俄罗斯联邦, Moscow

A. Rubina

V. A. Engelhardt Institute of Molecular Biology, Russian Academy of Sciences

Email: alex.tihonoff@gmail.com
俄罗斯联邦, Moscow

N. Kushlinskii

N. N. Blokhin National Medical Research Center of Oncology, Ministry of Health of the Russian Federation

Email: alex.tihonoff@gmail.com
俄罗斯联邦, Moscow

补充文件

附件文件
动作
1. JATS XML

版权所有 © Springer Science+Business Media, LLC, part of Springer Nature, 2019