Effect of ICa,L Blockade on Adrenergic Stimulation in Developing Heart
- 作者: Zefirov T.L.1, Kuptsova A.M.1, Biktemirova R.G.1, Ziyatdinova N.I.1, Zefirov A.L.2
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隶属关系:
- Department of Human Health Protection, Kazan (Volga Region) Federal University
- Department of Normal Physiology, Kazan StateMedical University
- 期: 卷 161, 编号 6 (2016)
- 页面: 746-748
- 栏目: Article
- URL: https://ogarev-online.ru/0007-4888/article/view/237745
- DOI: https://doi.org/10.1007/s10517-016-3500-5
- ID: 237745
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详细
The effect of verapamil-induced blockade of L-type calcium ionic currents (ICa,L) on the action of non-selective adrenergic cardiac stimulation by norepinephrine was examined during different periods of early postnatal ontogeny. In 1-week-old rats, intravenous norepinephrine induced a short-term tachycardia both with and without preliminary injected verapamil. In 3-week-old rats, norepinephrine alone produced no chronotropic effect; in contrast, it induced a biphasic tachycardia in verapamil-treated rats. In 6- and 20-month-old rats, norepinephrine induced a short-term tachycardia, which could be prevented by verapamil. The age-related peculiarities of chronotropic action of non-selective adrenergic stimulation are indicative of the role of L-type calcium ionic channels in the development of sympathetic control over the heart.
作者简介
T. Zefirov
Department of Human Health Protection, Kazan (Volga Region) Federal University
编辑信件的主要联系方式.
Email: zefirovtl@mail.ru
俄罗斯联邦, Kazan
A. Kuptsova
Department of Human Health Protection, Kazan (Volga Region) Federal University
Email: zefirovtl@mail.ru
俄罗斯联邦, Kazan
R. Biktemirova
Department of Human Health Protection, Kazan (Volga Region) Federal University
Email: zefirovtl@mail.ru
俄罗斯联邦, Kazan
N. Ziyatdinova
Department of Human Health Protection, Kazan (Volga Region) Federal University
Email: zefirovtl@mail.ru
俄罗斯联邦, Kazan
A. Zefirov
Department of Normal Physiology, Kazan StateMedical University
Email: zefirovtl@mail.ru
俄罗斯联邦, Kazan, the Republic of Tatarstan
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