Отправить статью по E-mail Effect of Lithium Preparations on Cerebral Electrophysiological Activity in Rats
- Авторы: Konenkov V.I.1, Rachkovskaya L.N.1, Letyagin A.Y.1, Suslov N.I.2, Shurlygina A.V.1, Robinson M.V.1, Korolev M.A.1, Kotlyarova A.A.1, Popova T.V.1, Rachkovskii E.E.1, Povet’eva T.N.2, Shilova N.V.2, Nesterova Y.V.2, Afanas’eva O.G.2, Kul’pin P.V.2
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Учреждения:
- Research Institute of Clinical and Experimental Lymphology, Affiliated Branch of Federal Research Center of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences
- E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center, Russian Academy of Sciences
- Выпуск: Том 165, № 4 (2018)
- Страницы: 470-473
- Раздел: Article
- URL: https://ogarev-online.ru/0007-4888/article/view/240426
- DOI: https://doi.org/10.1007/s10517-018-4196-5
- ID: 240426
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Аннотация
The study examined the effects of a novel neurotropic medication based on a lithium complex composed of lithium citrate, polymethylsiloxane, and aluminum oxide on electrophysiological parameters of the rat brain. In contrast to lithium carbonate (the reference drug), the novel preparation resulted in a wave-like dynamics of electrical activity in the visual cortex. Rhythmic photic stimulation of the rats treated with lithium carbonate resulted in appearance of the signs attesting to up-regulation of excitability of cerebral cortex in all examined ranges. In contrast, the complex lithium preparation diminished the delta power spectrum, which was the only affected frequency band. It is hypothesized that the complex lithium medication induces milder activation of the cerebral cortex in comparison with lithium carbonate. The novel medication composed of lithium citrate, aluminum oxide, and polymethylsiloxane, is characterized by greater efficacy and safety than the preparation based on inorganic lithium salt (lithium carbonate).
Об авторах
V. Konenkov
Research Institute of Clinical and Experimental Lymphology, Affiliated Branch of Federal Research Center of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences
Email: anna_v_s@mail.ru
Россия, Novosibirsk
L. Rachkovskaya
Research Institute of Clinical and Experimental Lymphology, Affiliated Branch of Federal Research Center of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences
Email: anna_v_s@mail.ru
Россия, Novosibirsk
A. Letyagin
Research Institute of Clinical and Experimental Lymphology, Affiliated Branch of Federal Research Center of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences
Email: anna_v_s@mail.ru
Россия, Novosibirsk
N. Suslov
E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center, Russian Academy of Sciences
Email: anna_v_s@mail.ru
Россия, Tomsk
A. Shurlygina
Research Institute of Clinical and Experimental Lymphology, Affiliated Branch of Federal Research Center of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences
Автор, ответственный за переписку.
Email: anna_v_s@mail.ru
Россия, Novosibirsk
M. Robinson
Research Institute of Clinical and Experimental Lymphology, Affiliated Branch of Federal Research Center of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences
Email: anna_v_s@mail.ru
Россия, Novosibirsk
M. Korolev
Research Institute of Clinical and Experimental Lymphology, Affiliated Branch of Federal Research Center of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences
Email: anna_v_s@mail.ru
Россия, Novosibirsk
A. Kotlyarova
Research Institute of Clinical and Experimental Lymphology, Affiliated Branch of Federal Research Center of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences
Email: anna_v_s@mail.ru
Россия, Novosibirsk
T. Popova
Research Institute of Clinical and Experimental Lymphology, Affiliated Branch of Federal Research Center of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences
Email: anna_v_s@mail.ru
Россия, Novosibirsk
E. Rachkovskii
Research Institute of Clinical and Experimental Lymphology, Affiliated Branch of Federal Research Center of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences
Email: anna_v_s@mail.ru
Россия, Novosibirsk
T. Povet’eva
E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center, Russian Academy of Sciences
Email: anna_v_s@mail.ru
Россия, Tomsk
N. Shilova
E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center, Russian Academy of Sciences
Email: anna_v_s@mail.ru
Россия, Tomsk
Yu. Nesterova
E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center, Russian Academy of Sciences
Email: anna_v_s@mail.ru
Россия, Tomsk
O. Afanas’eva
E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center, Russian Academy of Sciences
Email: anna_v_s@mail.ru
Россия, Tomsk
P. Kul’pin
E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center, Russian Academy of Sciences
Email: anna_v_s@mail.ru
Россия, Tomsk
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