Chronopharmacological Characteristics of the Effect of Hepatoprotectors in Experiment?

N. D. Bunyatyan; E. A. Kal’ko; S. M. Drogovoz; A. V. Kononenko

doi:10.1007/s10517-018-4258-8

Chronopharmacological Characteristics of the Effect of Hepatoprotectors in Experiment?

Autores: Bunyatyan N.D.¹, Kal’ko E.A.², Drogovoz S.M.², Kononenko A.V.²
Afiliações:
1. I. M. Sechenov First Moscow Medical University, the Ministry of Health of Russia
2. National Pharmaceutical University
Edição: Volume 165, Nº 6 (2018)
Páginas: 754-757
Seção: Article
URL: https://ogarev-online.ru/0007-4888/article/view/240725
DOI: https://doi.org/10.1007/s10517-018-4258-8
ID: 240725

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We studied circadian rhythms of activity of hepatoprotectors (Antral, Carsil, and glutargin) under conditions of acute paracetamol-induced hepatitis simulated in the morning, afternoon, evening, and at night (09.00, 15.00, 21.00, and 03.00). Antral and Carsil exhibited similar chronoprofiles with the maximum hepatoprotective activity at 09.00 and 21.00, while glutargin exhibited circadian pattern opposite and its activity was maximum at 15.00 and 03.00.