Мақаланы E-mail арқылы жіберу Application of Tetrameric Recombinant Human Butyrylcholinesterase as a Biopharmaceutical for Amelioration of Symptoms of Acute Organophosphate Poisoning
- Авторлар: Terekhov S.S.1, Palikov V.A.2, Palikova Y.A.2, Dyachenko I.A.2, Shamborant O.G.1, Smirnov I.V.1, Masson P.3, Gabibov A.G.1
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Мекемелер:
- V. V. Shemyakin and Yu. A. Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences
- Affiliated Branch of V. V. Shemyakin and Yu. A. Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences
- Kazan (Volga Region) Federal University
- Шығарылым: Том 163, № 4 (2017)
- Беттер: 430-435
- Бөлім: Article
- URL: https://ogarev-online.ru/0007-4888/article/view/238965
- DOI: https://doi.org/10.1007/s10517-017-3821-z
- ID: 238965
Дәйексөз келтіру
Ашық рұқсат
Рұқсат берілді
Тек жазылушылар үшін
Аннотация
We present a procedure for optimizing the expression of recombinant tetrameric butyrylcholinesterase that enables large-scale production with the yield >30 mg/liter (>90 mg/roller bottle). Intravenous injection of the preparation significantly increased survival and decreased the severity of symptoms of poisoning with paraoxon, an organophosphorus toxin.
Авторлар туралы
S. Terekhov
V. V. Shemyakin and Yu. A. Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences
Хат алмасуға жауапты Автор.
Email: sterekhoff@mail.ru
Ресей, Moscow
V. Palikov
Affiliated Branch of V. V. Shemyakin and Yu. A. Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences
Email: sterekhoff@mail.ru
Ресей, Pushchino, Moscow Region
Y. Palikova
Affiliated Branch of V. V. Shemyakin and Yu. A. Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences
Email: sterekhoff@mail.ru
Ресей, Pushchino, Moscow Region
I. Dyachenko
Affiliated Branch of V. V. Shemyakin and Yu. A. Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences
Email: sterekhoff@mail.ru
Ресей, Pushchino, Moscow Region
O. Shamborant
V. V. Shemyakin and Yu. A. Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences
Email: sterekhoff@mail.ru
Ресей, Moscow
I. Smirnov
V. V. Shemyakin and Yu. A. Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences
Email: sterekhoff@mail.ru
Ресей, Moscow
P. Masson
Kazan (Volga Region) Federal University
Email: sterekhoff@mail.ru
Ресей, Republic of Tatarstan, Kazan
A. Gabibov
V. V. Shemyakin and Yu. A. Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences
Email: sterekhoff@mail.ru
Ресей, Moscow
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