Algorithm of Molecular and Biological Assessment of the Mechanisms of Sensitivity to Drug Toxicity by the Example of Cyclophosphamide

L. Yu. Telegin; S. Kh. Sarmanaev; V. M. Devichenskii; V. A. Tutelyan

doi:10.1007/s10517-018-3982-4

Algorithm of Molecular and Biological Assessment of the Mechanisms of Sensitivity to Drug Toxicity by the Example of Cyclophosphamide

Авторы: Telegin L.Y.¹, Sarmanaev S.K.², Devichenskii V.M.², Tutelyan V.A.³
Учреждения:
1. Center for Theoretical Problems of Physicochemical Pharmacology, Russian Academy of Sciences
2. Institute for Advanced Studies, Federal Medical-Biological Agency
3. Federal Research Centre of Nutrition, Biotechnology and Food Safety
Выпуск: Том 164, № 3 (2018)
Страницы: 324-329
Раздел: Article
URL: https://ogarev-online.ru/0007-4888/article/view/239578
DOI: https://doi.org/10.1007/s10517-018-3982-4
ID: 239578

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Comparative study of the liver, blood, and spleen of DBA/2JSto and BALB/cJLacSto mice sensitive and resistant to acute toxicity of the cyclophosphamide allowed us to reveal basic toxicity biomarkers of this antitumor and immunosuppressive agent. Obtained results can be used for the development of an algorithm for evaluation of toxic effects of drugs and food components.