Role of JAK1, JAK2, and JAK3 in Functional Stimulation of Mesenchymal Precursor Cells by Alkaloid Songorine

G. N. Zyuz’kov; E. V. Udut; L. A. Miroshnichenko; E. V. Simanina; T. Yu. Polyakova; L. A. Stavrova; V. V. Udut; M. Yu. Minakova; A. M. Dygai; A. V. Chaikovskii; V. I. Agafonov; V. V. Zhdanov

doi:10.1007/s10517-017-3824-9

Role of JAK1, JAK2, and JAK3 in Functional Stimulation of Mesenchymal Precursor Cells by Alkaloid Songorine

Authors: Zyuz’kov G.N.¹^,2, Udut E.V.¹, Miroshnichenko L.A.¹, Simanina E.V.¹, Polyakova T.Y.¹, Stavrova L.A.¹, Udut V.V.¹^,2, Minakova M.Y.¹, Dygai A.M.¹, Chaikovskii A.V.¹, Agafonov V.I.¹, Zhdanov V.V.¹
Affiliations:
1. E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine
2. Laboratory of Modeling of Physical Processes in Biology and Medicine, National Research Tomsk State University
Issue: Vol 163, No 4 (2017)
Pages: 443-446
Section: Article
URL: https://ogarev-online.ru/0007-4888/article/view/238974
DOI: https://doi.org/10.1007/s10517-017-3824-9
ID: 238974

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Abstract

We studied the role of some JAK in the effect of diterpene alkaloid songorine on realization of the growth potential of mesenchymal precursor cells. The participation of JAK1, JAK2, and JAK3 in stimulation of proliferation of the precursor cells was demonstrated. Specific inhibitors of these JAK reduced the yield of fibroblast CFU and the rate of their division. Inhibition of JAK2 against the background of songorine treatment increased the rate of precursor differentiation.

About the authors

G. N. Zyuz’kov

E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine; Laboratory of Modeling of Physical Processes in Biology and Medicine, National Research Tomsk State University

Author for correspondence.
Email: zgn@pharmso.ru
Russian Federation, Tomsk; Tomsk