Effect of Polypeptides on Cell Proliferation and Apoptosis during Aging
- Авторлар: Ryzhak A.1, Chalisova N.I.1,2, Lin’kova N.S.1,2,3, Nichik T.E.2, Dudkov A.2, Kolchina N.V.1, Ryzhak G.A.1, Khalimov R.I.1
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Мекемелер:
- St. Petersburg Institute of Bioregulation and Gerontology
- I. P. Pavlov Institute of Physiology, Russian Academy of Sciences
- Peter the Great St.Petersburg Polytechnic University
- Шығарылым: Том 162, № 4 (2017)
- Беттер: 534-538
- Бөлім: Article
- URL: https://ogarev-online.ru/0007-4888/article/view/238355
- DOI: https://doi.org/10.1007/s10517-017-3655-8
- ID: 238355
Дәйексөз келтіру
Аннотация
Polypeptide complexes derived from the bronchi, blood vessels, muscles, kidneys, ovaries, testes, and retina stimulated the processes of cell renewal in organotypic cultures of the corresponding organs of young and old animals. A correlation between the intensity of regeneration and animal’ age was revealed. The polypeptide complexes reduced the expression of apoptotic factors p53 and caspase 3 and increased the expression of proliferation protein Ki-67. These results provide the basis for further study of the polypeptide complexes as stimulators of regenerative processes in different tissues during ageing.
Авторлар туралы
A.P. Ryzhak
St. Petersburg Institute of Bioregulation and Gerontology
Email: miayy@yandex.ru
Ресей, St. Petersburg
N. Chalisova
St. Petersburg Institute of Bioregulation and Gerontology; I. P. Pavlov Institute of Physiology, Russian Academy of Sciences
Email: miayy@yandex.ru
Ресей, St. Petersburg; St. Petersburg
N. Lin’kova
St. Petersburg Institute of Bioregulation and Gerontology; I. P. Pavlov Institute of Physiology, Russian Academy of Sciences; Peter the Great St.Petersburg Polytechnic University
Хат алмасуға жауапты Автор.
Email: miayy@yandex.ru
Ресей, St. Petersburg; St. Petersburg; St. Petersburg
T. Nichik
I. P. Pavlov Institute of Physiology, Russian Academy of Sciences
Email: miayy@yandex.ru
Ресей, St. Petersburg
A.V. Dudkov
I. P. Pavlov Institute of Physiology, Russian Academy of Sciences
Email: miayy@yandex.ru
Ресей, St. Petersburg
N. Kolchina
St. Petersburg Institute of Bioregulation and Gerontology
Email: miayy@yandex.ru
Ресей, St. Petersburg
G. Ryzhak
St. Petersburg Institute of Bioregulation and Gerontology
Email: miayy@yandex.ru
Ресей, St. Petersburg
R. Khalimov
St. Petersburg Institute of Bioregulation and Gerontology
Email: miayy@yandex.ru
Ресей, St. Petersburg
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