Effect of Polypeptides on Cell Proliferation and Apoptosis during Aging


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Аннотация

Polypeptide complexes derived from the bronchi, blood vessels, muscles, kidneys, ovaries, testes, and retina stimulated the processes of cell renewal in organotypic cultures of the corresponding organs of young and old animals. A correlation between the intensity of regeneration and animal’ age was revealed. The polypeptide complexes reduced the expression of apoptotic factors p53 and caspase 3 and increased the expression of proliferation protein Ki-67. These results provide the basis for further study of the polypeptide complexes as stimulators of regenerative processes in different tissues during ageing.

Авторлар туралы

A.P. Ryzhak

St. Petersburg Institute of Bioregulation and Gerontology

Email: miayy@yandex.ru
Ресей, St. Petersburg

N. Chalisova

St. Petersburg Institute of Bioregulation and Gerontology; I. P. Pavlov Institute of Physiology, Russian Academy of Sciences

Email: miayy@yandex.ru
Ресей, St. Petersburg; St. Petersburg

N. Lin’kova

St. Petersburg Institute of Bioregulation and Gerontology; I. P. Pavlov Institute of Physiology, Russian Academy of Sciences; Peter the Great St.Petersburg Polytechnic University

Хат алмасуға жауапты Автор.
Email: miayy@yandex.ru
Ресей, St. Petersburg; St. Petersburg; St. Petersburg

T. Nichik

I. P. Pavlov Institute of Physiology, Russian Academy of Sciences

Email: miayy@yandex.ru
Ресей, St. Petersburg

A.V. Dudkov

I. P. Pavlov Institute of Physiology, Russian Academy of Sciences

Email: miayy@yandex.ru
Ресей, St. Petersburg

N. Kolchina

St. Petersburg Institute of Bioregulation and Gerontology

Email: miayy@yandex.ru
Ресей, St. Petersburg

G. Ryzhak

St. Petersburg Institute of Bioregulation and Gerontology

Email: miayy@yandex.ru
Ресей, St. Petersburg

R. Khalimov

St. Petersburg Institute of Bioregulation and Gerontology

Email: miayy@yandex.ru
Ресей, St. Petersburg

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