Отправить статью по E-mail Evaluation of the Hepatoprotective Effect of L-Ascorbate 1-(2-Hydroxyethyl)-4,6-Dimethyl-1,2-Dihydropyrimidine-2-One Upon Exposure to Carbon Tetrachloride
- Авторы: Vyshtakalyuk A.B.1, Nazarov N.G.1,2, Zobov V.V.1,2, Abdulkhakov S.R.2, Minnekhanova O.A.1, Semenov V.E.1, Galyametdinova I.V.1, Cherepnev G.V.1,3, Reznik V.S.1
-
Учреждения:
- A. E. Arbuzov Institute of Organic and Physical Chemistry, Kazan Research Center of the Russian Academy of Sciences
- Kazan (Volga Region) Federal University
- Medical Unit of Kazan (Volga Region) Federal University
- Выпуск: Том 162, № 3 (2017)
- Страницы: 340-342
- Раздел: Article
- URL: https://ogarev-online.ru/0007-4888/article/view/238182
- DOI: https://doi.org/10.1007/s10517-017-3610-8
- ID: 238182
Цитировать
Открытый доступ
Доступ предоставлен
Только для подписчиков
Аннотация
Hepatoprotective properties of a new pyrimidine derivative — L-ascorbate 1-(2-hydroxyethyl)-4,6-dimethyl-1,2-dihydropyrimidine-2-one, synthesized on the basis Xymedon, were assessed in white rats exposed to CCl4. The compound under study administered prior to exposure to CCl4 reduced the deviation of biochemical parameters from reference values and severity of structural and morphological changes in liver, when compared to the control. Hepatoprotective properties of the studied compound were more pronounced than those of Xymedon.
Об авторах
A. Vyshtakalyuk
A. E. Arbuzov Institute of Organic and Physical Chemistry, Kazan Research Center of the Russian Academy of Sciences
Автор, ответственный за переписку.
Email: alex.vysh@mail.ru
Россия, Kazan
N. Nazarov
A. E. Arbuzov Institute of Organic and Physical Chemistry, Kazan Research Center of the Russian Academy of Sciences; Kazan (Volga Region) Federal University
Email: alex.vysh@mail.ru
Россия, Kazan; Kazan
V. Zobov
A. E. Arbuzov Institute of Organic and Physical Chemistry, Kazan Research Center of the Russian Academy of Sciences; Kazan (Volga Region) Federal University
Email: alex.vysh@mail.ru
Россия, Kazan; Kazan
S. Abdulkhakov
Kazan (Volga Region) Federal University
Email: alex.vysh@mail.ru
Россия, Kazan
O. Minnekhanova
A. E. Arbuzov Institute of Organic and Physical Chemistry, Kazan Research Center of the Russian Academy of Sciences
Email: alex.vysh@mail.ru
Россия, Kazan
V. Semenov
A. E. Arbuzov Institute of Organic and Physical Chemistry, Kazan Research Center of the Russian Academy of Sciences
Email: alex.vysh@mail.ru
Россия, Kazan
I. Galyametdinova
A. E. Arbuzov Institute of Organic and Physical Chemistry, Kazan Research Center of the Russian Academy of Sciences
Email: alex.vysh@mail.ru
Россия, Kazan
G. Cherepnev
A. E. Arbuzov Institute of Organic and Physical Chemistry, Kazan Research Center of the Russian Academy of Sciences; Medical Unit of Kazan (Volga Region) Federal University
Email: alex.vysh@mail.ru
Россия, Kazan; Kazan
V. Reznik
A. E. Arbuzov Institute of Organic and Physical Chemistry, Kazan Research Center of the Russian Academy of Sciences
Email: alex.vysh@mail.ru
Россия, Kazan
Дополнительные файлы
