The Antioxidant Activity of Ceruloplasmin in Rhabdomyolysis-Induced Acute Kidney Injury

Abstract

Abstract—Rhabdomyolysis is a life-threatening syndrome that may occur after skeletal muscle injury; in 10 to 40% of cases, it leads to acute renal tubular necrosis and acute kidney injury induced by myoglobin release from damaged myocytes. Reactive oxygen species and oxidative stress are major determinants of acute kidney injury. One of the principal antioxidants in the blood plasma is ceruloplasmin, which performs many physiological functions. The effects of ceruloplasmin on renal function and the prooxidant–antioxidant balance in the kidneys and blood were studied in adult non-linear white rats with experimental rhabdomyolysis. It was found that prophylactic administration of ceruloplasmin had a renoprotective effect; it improved renal function, reduced the intensity of lipid and protein peroxidation, and increased the activity of glutathione peroxidase in kidney tissue and blood, as well as the levels of ceruloplasmin and molecules with SH-groups in the blood plasma.