Email this article The Sensitivity of Human Tumor Cells to the Cytotoxicity of Gold Polyacrylate (Aurumacryl)
- Authors: Korman D.B.1, Nekrasova E.I.1, Ostrovskaya L.A.1, Ryabaya O.O.2, Bluhterova N.V.1, Abzaeva K.A.3
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Affiliations:
- Emanuel Institute of Biochemical Physics, Russian Academy of Sciences
- Blokhin National Medical Research Center for Oncology, Ministry of Health of the Russian Federation
- Favorsky Irkutsk Institute of Chemistry, Siberian Branch, Russian Academy of Sciences
- Issue: Vol 64, No 6 (2019)
- Pages: 930-935
- Section: Cell Biophysics
- URL: https://ogarev-online.ru/0006-3509/article/view/153148
- DOI: https://doi.org/10.1134/S0006350919060125
- ID: 153148
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Abstract
The cytotoxic effect of the antitumor drug aurumacryl (gold polyacrylate) against human tumor cells of various origins has been studied. It has been shown that aurumacryl exhibits significant cytotoxic activity against cells of lung carcinoma А549 (IC50 = 60 μg/mL), melanoma Mel-mо (IC50 = 80 μg/mL), and breast carcinoma MCF-7 (IC50 = 90 μg/mL), while being substantially less efficient against colon carcinoma НСТ116 cells (IC50 = 180 μg/mL).
About the authors
D. B. Korman
Emanuel Institute of Biochemical Physics, Russian Academy of Sciences
Author for correspondence.
Email: larros@list.ru
Russian Federation, Moscow, 119334
E. I. Nekrasova
Emanuel Institute of Biochemical Physics, Russian Academy of Sciences
Email: larros@list.ru
Russian Federation, Moscow, 119334
L. A. Ostrovskaya
Emanuel Institute of Biochemical Physics, Russian Academy of Sciences
Email: larros@list.ru
Russian Federation, Moscow, 119334
O. O. Ryabaya
Blokhin National Medical Research Center for Oncology, Ministry of Health of the Russian Federation
Email: larros@list.ru
Russian Federation, Moscow, 115478
N. V. Bluhterova
Emanuel Institute of Biochemical Physics, Russian Academy of Sciences
Email: larros@list.ru
Russian Federation, Moscow, 119334
K. A. Abzaeva
Favorsky Irkutsk Institute of Chemistry, Siberian Branch, Russian Academy of Sciences
Email: larros@list.ru
Russian Federation, Irkutsk, 664033
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