The Sensitivity of Human Tumor Cells to the Cytotoxicity of Gold Polyacrylate (Aurumacryl)

D. B. Korman; E. I. Nekrasova; L. A. Ostrovskaya; O. O. Ryabaya; N. V. Bluhterova; K. A. Abzaeva

doi:10.1134/S0006350919060125

The Sensitivity of Human Tumor Cells to the Cytotoxicity of Gold Polyacrylate (Aurumacryl)

作者: Korman D.B.¹, Nekrasova E.I.¹, Ostrovskaya L.A.¹, Ryabaya O.O.², Bluhterova N.V.¹, Abzaeva K.A.³
隶属关系:
1. Emanuel Institute of Biochemical Physics, Russian Academy of Sciences
2. Blokhin National Medical Research Center for Oncology, Ministry of Health of the Russian Federation
3. Favorsky Irkutsk Institute of Chemistry, Siberian Branch, Russian Academy of Sciences
期: 卷 64, 编号 6 (2019)
页面: 930-935
栏目: Cell Biophysics
URL: https://ogarev-online.ru/0006-3509/article/view/153148
DOI: https://doi.org/10.1134/S0006350919060125
ID: 153148

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The cytotoxic effect of the antitumor drug aurumacryl (gold polyacrylate) against human tumor cells of various origins has been studied. It has been shown that aurumacryl exhibits significant cytotoxic activity against cells of lung carcinoma А549 (IC₅₀ = 60 μg/mL), melanoma Mel-mо (IC₅₀ = 80 μg/mL), and breast carcinoma MCF-7 (IC₅₀ = 90 μg/mL), while being substantially less efficient against colon carcinoma НСТ116 cells (IC₅₀ = 180 μg/mL).