Email this article A Multisensory Stripping Voltammetry Method for Analysis of the Generic Anti-Glaucoma Drug Betoptic
- Authors: Balashova L.M.1,2, Kolesnichenko I.I.3, Namiot V.A.4, Doronin A.N.3, Bakunina N.A.1, Kuznetsova Y.D.1,2, Udaltsov S.N.5
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Affiliations:
- International Scientific and Practical Center for Tissue Proliferation
- Pirogov Russian National Research Medical University
- Frumkin Institute of Physical Chemistry and Electrochemistry, Russian Academy of Sciences
- Institute of Nuclear Physics, Moscow State University
- Institute of Physicochemical and Biological Problems in Soil Science, Russian Academy of Sciences
- Issue: Vol 64, No 6 (2019)
- Pages: 885-889
- Section: Molecular Biophysics
- URL: https://ogarev-online.ru/0006-3509/article/view/153134
- DOI: https://doi.org/10.1134/S0006350919060046
- ID: 153134
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Abstract
A new electrochemical method for multisensory stripping voltammetry has been used to determine whether it is appropriate for determination of generic forms of the drug Betoptic, that is, Xonef, Betoftan, and Betalink EU in tear fluid. Measurements were carried out on a planar three-electrode interdigitated electrode. It has been shown that this method is effective for determination of the generics. The dynamics of changes in their concentrations over time were examined. After instillation of the generics in glaucoma patients, their concentrations in the lacrimal fluid remained unchanged within 12 h. The list of organic substances that can be determined by the method of multisensory stripping voltammetry has been extended.
About the authors
L. M. Balashova
International Scientific and Practical Center for Tissue Proliferation; Pirogov Russian National Research Medical University
Email: vnamiot@gmail.com
Russian Federation, Moscow, 119034; Moscow, 117997
I. I. Kolesnichenko
Frumkin Institute of Physical Chemistry and Electrochemistry, Russian Academy of Sciences
Email: vnamiot@gmail.com
Russian Federation, Moscow, 119071
V. A. Namiot
Institute of Nuclear Physics, Moscow State University
Author for correspondence.
Email: vnamiot@gmail.com
Russian Federation, Moscow, 119991
A. N. Doronin
Frumkin Institute of Physical Chemistry and Electrochemistry, Russian Academy of Sciences
Email: vnamiot@gmail.com
Russian Federation, Moscow, 119071
N. A. Bakunina
International Scientific and Practical Center for Tissue Proliferation
Email: vnamiot@gmail.com
Russian Federation, Moscow, 119034
Yu. D. Kuznetsova
International Scientific and Practical Center for Tissue Proliferation; Pirogov Russian National Research Medical University
Email: vnamiot@gmail.com
Russian Federation, Moscow, 119034; Moscow, 117997
S. N. Udaltsov
Institute of Physicochemical and Biological Problems in Soil Science, Russian Academy of Sciences
Email: vnamiot@gmail.com
Russian Federation, Pushchino, Moscow oblast, 142290
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