Email this article The response of the mononuclear phagocyte system to chronic hyperglycemia
- Authors: Bulavintseva T.S.1,2, Danilova I.G.1,2,3, Briliant S.A.1,2,3, Smirnyh S.E.1,2, Abidov M.T.4
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Affiliations:
- Ural Federal University named after the first President of Russia B.N. Yeltsin
- Institute of Immunology and Physiology, Ural Branch
- Institute of Medical Cell Technologies
- Institute of Immunopathology
- Issue: Vol 61, No 6 (2016)
- Pages: 919-922
- Section: Cell Biophysics
- URL: https://ogarev-online.ru/0006-3509/article/view/152159
- DOI: https://doi.org/10.1134/S0006350916050031
- ID: 152159
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Abstract
In this study we revealed a common reaction of cells of the mononuclear phagocyte system in the central and peripheral immunopoietic organs and pancreas in rats with chronic hyperglycemia. The activation of monocytopoiesis and recruitment of mononuclear phagocytes in peripheral tissues were observed. The modulation of the functional activity of mononuclear phagocytes by 3-aminophthal-hydrazide contributed to the normalization of monocytopoietic intensity and a decrease in the level of macrophagal infiltration in the thymus, pancreas, and peripancreatic lymph nodes. These changes indicate that mononuclear phagocytes are involved in the adaptive response to chronic hyperglycemia.
About the authors
T. S. Bulavintseva
Ural Federal University named after the first President of Russia B.N. Yeltsin; Institute of Immunology and Physiology, Ural Branch
Author for correspondence.
Email: omella@yandex.ru
Russian Federation, ul. Mira 19, Yekaterinburg, 620002; ul. Pervomaiskaya 106, Yekaterinburg, 620049
I. G. Danilova
Ural Federal University named after the first President of Russia B.N. Yeltsin; Institute of Immunology and Physiology, Ural Branch; Institute of Medical Cell Technologies
Email: omella@yandex.ru
Russian Federation, ul. Mira 19, Yekaterinburg, 620002; ul. Pervomaiskaya 106, Yekaterinburg, 620049; ul. K. Marksa 22a, Yekaterinburg, 620026
S. A. Briliant
Ural Federal University named after the first President of Russia B.N. Yeltsin; Institute of Immunology and Physiology, Ural Branch; Institute of Medical Cell Technologies
Email: omella@yandex.ru
Russian Federation, ul. Mira 19, Yekaterinburg, 620002; ul. Pervomaiskaya 106, Yekaterinburg, 620049; ul. K. Marksa 22a, Yekaterinburg, 620026
S. E. Smirnyh
Ural Federal University named after the first President of Russia B.N. Yeltsin; Institute of Immunology and Physiology, Ural Branch
Email: omella@yandex.ru
Russian Federation, ul. Mira 19, Yekaterinburg, 620002; ul. Pervomaiskaya 106, Yekaterinburg, 620049
M. T. Abidov
Institute of Immunopathology
Email: omella@yandex.ru
Russian Federation, ul. Molodogvardeiskaya 57/1, Moscow, 121351
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