Cell response to extremely weak static magnetic fields


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Abstract

The effect of an extremely weak static magnetic field (EWSMF) was studied in diploid fibroblast strains that originated from a healthy donor and an ataxia–telangiectasia patient. Indirect immunofluorescence was used to detect p53, p53BP1, and p21. The pattern that occurred in donor cells exposed to EWSMF similar to that observed in DNA damage, viz., the p53 and p21 levels increased and p3BP1 foci formed. No visible change was observed in primary fibroblasts from the ataxia–telangiectasia patient. The results implicate ATM signaling in the fibroblast response to EWSMF.

About the authors

I. M. Spivak

Institute of Cytology; St. Petersburg State University; St. Petersburg Polytechnic University

Email: stefanov@bio.spbu.ru
Russian Federation, Tikhoretskii pr. 4, St. Petersburg, 194064; Universitetskaya nab. 7/9, St. Petersburg, 199034; ul. Politekhnicheskaya 29, St. Petersburg, 195251

M. L. Kuranova

Institute of Cytology

Email: stefanov@bio.spbu.ru
Russian Federation, Tikhoretskii pr. 4, St. Petersburg, 194064

G. R. Mavropulo-Stolyarenko

St. Petersburg State University

Email: stefanov@bio.spbu.ru
Russian Federation, Universitetskaya nab. 7/9, St. Petersburg, 199034

S. V. Surma

Pavlov Institute of Physiology

Email: stefanov@bio.spbu.ru
Russian Federation, nab. Makarova 6, St. Petersburg, 199034

B. F. Shchegolev

Pavlov Institute of Physiology; Almazov Federal Medical Research Center

Email: stefanov@bio.spbu.ru
Russian Federation, nab. Makarova 6, St. Petersburg, 199034; ul. Akkuratova 2, St. Petersburg, 197341

V. E. Stefanov

St. Petersburg State University

Author for correspondence.
Email: stefanov@bio.spbu.ru
Russian Federation, Universitetskaya nab. 7/9, St. Petersburg, 199034

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