Mitochondrial DNA Deletion in Offspring of Female Mice Exposed to X-Rays

Аннотация

Abstract—The effects of X-ray exposure on the mitochondrial genome were studied in the offspring of female mice exposed in the preconception period at doses of 0.5 and 2 Gy. Radiation effects were evaluated by the proportion of offspring with a 4974-bp mtDNA deletion. The results showed that irradiation of female mice at these doses did not increase the proportion of offspring with the mtDNA deletion in the brain, spleen, and peripheral blood cells.