Biophysical mechanisms of contact activation of blood-plasma clotting
- Авторы: Terent’eva V.A.1,2, Sveshnikova A.N.1,2,3,4, Panteleev M.A.1,2,3,5
-
Учреждения:
- Department of Physics
- Rogachev Federal Research and Clinical Center of Pediatric Hematology
- Center for Theoretical Problems of Physico-Chemical Pharmacology
- Pirogov Russian National Research Medical University
- Faculty of Biological and Medical Physics
- Выпуск: Том 62, № 5 (2017)
- Страницы: 742-753
- Раздел: Cell Biophysics
- URL: https://ogarev-online.ru/0006-3509/article/view/152394
- DOI: https://doi.org/10.1134/S0006350917050232
- ID: 152394
Цитировать
Аннотация
This review considers the biochemical and biophysical mechanisms that trigger blood clotting upon contact of blood with an alien surface and leads via a cascade of enzymatic reactions to fibrin polymerization and the formation of a blood plasma clot, which permeates a primary platelet aggregate to produce a dense hemostatic clot. In spite of the substantial number of experimental and theoretical studies on the subject, there is still no consistent opinion as to what processes occur as the blood plasma contacts a surface. This review discusses the role that plasma protein factor XII and various surfaces play in triggering the contact pathway in vivo and in vitro. Current views of the molecular events that underlie the process are described.
Ключевые слова
Об авторах
V. Terent’eva
Department of Physics; Rogachev Federal Research and Clinical Center of Pediatric Hematology
Автор, ответственный за переписку.
Email: terenteva@physics.msu.ru
Россия, Moscow, 119991; Moscow, 117997
A. Sveshnikova
Department of Physics; Rogachev Federal Research and Clinical Center of Pediatric Hematology; Center for Theoretical Problems of Physico-Chemical Pharmacology; Pirogov Russian National Research Medical University
Email: terenteva@physics.msu.ru
Россия, Moscow, 119991; Moscow, 117997; Moscow, 119991; Moscow, 117997
M. Panteleev
Department of Physics; Rogachev Federal Research and Clinical Center of Pediatric Hematology; Center for Theoretical Problems of Physico-Chemical Pharmacology; Faculty of Biological and Medical Physics
Email: terenteva@physics.msu.ru
Россия, Moscow, 119991; Moscow, 117997; Moscow, 119991; Dologoprudnyi, Moscow oblast, 141700
Дополнительные файлы
