The efficiency of blood photomodification with therapeutic doses of optical radiation of different wavelengths

Resumo

Spectra of radiation penetration depth into the blood and skin tissues were calculated for the wavelength range of 405 to 950 nm with the optical properties of biological tissues taken into account. The proportion of radiation that reached the blood in the blood vessel in the case of supravenous irradiation of blood was estimated. Optimal wavelengths that allowed efficient formation of molecular oxygen in the blood due to photodissociation of oxyhemoglobin upon intravenous and supravenous irradiation of blood were determined. Changes in blood oxygenation parameters characteristic of phototherapy, such as the degree of hemoglobin saturation with oxygen, oxyhemoglobin concentration, partial pressure of oxygen, and the concentrations of certain products of metabolism initiated by the photodissociation of oxyhemoglobin, have been demonstrated for optical radiation of different wavelengths. The physical causes of changes in oxygenation characteristics and metabolic product levels induced by photohemotherapy are considered.