Extension of the neuronal membrane model to account for suppression of the action potential by a constant magnetic field

Аннотация

A biophysical explanation of the reduced excitability in neurons exposed to a constant magnetic field is based on an extended neuronal membrane model. In the presence of a constant magnetic field, reduced excitability is manifested as an increase in the excitation threshold and a decrease in the frequency of action potentials. The proposed explanation for the reduced excitability rests on the well-known Hall effect. The separation of charges resulting from the Lorentz force exerted on moving intracellular ions leads to the formation of a Hall electric field in a direction perpendicular to that of action-potential transmission. Consequently, the ion current for discharging the membrane capacitance is reduced in the presence of a magnetic field, thereby limiting initiation of the action potential. The validity of the proposed biophysical explanation is justified analytically and verified by simulations based on the Hodgkin and Huxley model for the electrical excitability of a neuron. Based on derivation of the current segregation ratio α characterizing the reduction in the stimulating current from first principles, the equivalent circuit model of the neuronal membrane is extended to account for the reduced excitability of neurons exposed to a constant magnetic field.