Email this article The Molecular mechanism of the action of Helianthus tuberosus L. polysaccharide
- Authors: Generalov E.A.1, Afremova A.I.1
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Affiliations:
- Engelhardt Institute of Molecular Biology
- Issue: Vol 61, No 4 (2016)
- Pages: 558-564
- Section: Molecular Biophysics
- URL: https://ogarev-online.ru/0006-3509/article/view/152037
- DOI: https://doi.org/10.1134/S0006350916040096
- ID: 152037
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Abstract
Evidence for immunoadjuvant activity of the Helianthus tuberosus L. polysaccharide was obtained in an antibody-producing cell model. Dectin-1 and TLR-6 were identified as major receptors required for biological activity of polysaccharide in a TNF-α stimulation model. The CR3 receptor was not implicated in polysaccharide recognition in the same model. Enzyme treatment of the H. tuberosus L. polysaccharide demonstrated the presence of ß-(1 → 4) and ß-(1 → 3) glycosidic bonds.
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About the authors
E. A. Generalov
Engelhardt Institute of Molecular Biology
Author for correspondence.
Email: generals1179@gmail.com
Russian Federation, ul. Vavilova 32, Moscow, 119991
A. I. Afremova
Engelhardt Institute of Molecular Biology
Author for correspondence.
Email: afremova.a@gmail.com
Russian Federation, ul. Vavilova 32, Moscow, 119991
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