The effects of dimebon on mouse brain cell endoplasmic reticulum membrane viscosity in vivo

Abstract

The neuroprotective effects of dimebon on the microviscosity of endoplasmic reticulum membranes isolated from the mouse brain after chronic drug administration were studied. This study revealed that dimebon decreases the microviscosity of the near-protein regions of the microsomal membranes. This neuroprotector showed no effect on thermally induced structural transitions, as well as on the activation energy of the corresponding structural states. This apparently may be due to the insufficient neuroprotector concentration in the brain cells.