Endolysins T5 and PlyG Dynamics: Comparative Analysis in silico

Мұқаба

Дәйексөз келтіру

Толық мәтін

Ашық рұқсат Ашық рұқсат
Рұқсат жабық Рұқсат берілді
Рұқсат жабық Тек жазылушылар үшін

Аннотация

Bacteriophage endolysins are part of a lytic enzymes complex responsible for the destruction of the bacterial cell wall peptidoglycan. In this paper, the dynamic properties of bacteriophage T5 single-domain endolysin and the multi-domain endolysin PlyG of gamma phage are studied using molecular dynamics and normal mode analysis. The mechanism of activation of bacteriophage T5 endolysin by calcium and the discovery of a fundamental difference in the dynamic features of single-domain and multi-domain endolysins are explained.

Авторлар туралы

A. Arakelian

Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences

Email: arkatsachndir@gmail.com
Pushchino, Russia

G. Chuev

Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences

Pushchino, Russia

T. Mamedov

Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences

Pushchino, Russia

A. Arikov

The Agricultural University of Plovdiv

Plovdiv, Bulgaria

K. Ismailov

Olympic Reserve Sports School of Wrestling

Vladimir, Russia

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