Innovative Approach to Surgical Treatment for Locally Advanced Cancer of Paranasal Sinus and Nasal Cavity
- Authors: Kit O.I.1, Reshetov I.V.2,3, Engibaryan M.A.1
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Affiliations:
- National Medical Research Centre for Oncology
- I.M. Sechenov First Moscow State Medical University
- Federal Scientific and Clinical Center for Specialized Types of Medical Care and Medical Technologies of the Federal Medical and Biological Agency
- Issue: Vol 76, No 3 (2021)
- Pages: 317-323
- Section: ONCOLOGY: CURRENT ISSUES
- URL: https://ogarev-online.ru/vramn/article/view/125668
- DOI: https://doi.org/10.15690/vramn1393
- ID: 125668
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Abstract
Background. Despite the rapid oncology development, the problem of surgical treatment for locally advanced tumors of the paranasal sinus and nasal cavity is still relevant. The search and development of ways to improve the surgical approach, including modern endovascular methods, appears necessary. Aims — development and evaluation of the effectiveness of an innovative approach to the surgical treatment of malignant tumors of the nasal cavity and paranasal sinus with superselective intra-arterial embolization as a preparatory stage. Materials and methods. The study is based on the treatment outcomes of 52 patients with cancer of the nasal cavity and paranasal sinus. The main group included 21 patients receiving treatment with our developed approach including preoperative superselective intra-arterial embolization as a preparatory stage for surgical treatment. The control group included 31 patients receiving standard surgical treatment with traditional ligation of the external carotid artery at the first stage. Estimation of the amount of intraoperative blood loss with gravimetric analysis was considered the primary endpoint of the study. Post-embolization syndrome manifestations were analyzed by evaluating the pain intensity with a visual analogue scale and thermometry. Results. Intraoperative blood loss in patients of the main group varied from 100 to 400 ml, being on average 231.9±100.58 ml. In the control group, the blood loss varied from 300 ml to 1000 ml, on average 630.97±190.23. The data analysis proved demonstratively the effectiveness of the developed approach to surgical treatment of locally advanced tumors of the nasal cavity and paranasal sinus, since it statistically significantly reduced the amount of intoperative blood loss (p < 0.005). Conclusions. Our developed approach to the treatment for malignant tumors of the paranasal sinus and nasal cavity optimized the results of surgical treatment and statistically significantly reduced the amount of intoperative blood loss, compared to the traditional ligation of the external carotid artery, from 630.97±190.23 to 231.9±100.58 ml (p < 0.005), with minimal manifestations of post-embolization syndrome.
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##article.viewOnOriginalSite##About the authors
Oleg I. Kit
National Medical Research Centre for Oncology
Email: kit@aaanet.ru
ORCID iD: 0000-0003-3061-6108
SPIN-code: 1728-0329
MD, PhD, Professor, Corresponding Member of the RAS
Russian Federation, 63, 14th liniya, Rostov on Don, 344029Igor V. Reshetov
I.M. Sechenov First Moscow State Medical University; Federal Scientific and Clinical Center for Specialized Types of Medical Care and Medical Technologies of the Federal Medical and Biological Agency
Email: reshetoviv@mail.ru
ORCID iD: 0000-0002-0909-6278
SPIN-code: 3845-6604
MD, PhD, Professor, Academician of the RAS
Russian Federation, 8-2, Trubetskaya street, Moscow, 119991; 28, Walnut Boulevard, MoscowMarina A. Engibaryan
National Medical Research Centre for Oncology
Author for correspondence.
Email: mar457@yandex.ru
ORCID iD: 0000-0001-7293-2358
SPIN-code: 1764-0276
MD, PhD
Russian Federation, 63, 14th liniya, Rostov on Don, 344029References
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