Atopic dermatitis in children and specific IgE to Stahpylococcus aureus superantigens: a compare with disease severity
- 作者: Treneva MS1, Pampura AN1, Okuneva TS1
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隶属关系:
- Federal State Institution «Moscow Research Institute of Pediatrics and Child Surgery» by Ministry of Health and Social Welfare of Russia
- 期: 卷 9, 编号 4 (2012)
- 页面: 39-41
- 栏目: Articles
- URL: https://ogarev-online.ru/raj/article/view/121160
- DOI: https://doi.org/10.36691/RJA703
- ID: 121160
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详细
Background. Staphylococus aureus (S. aureus ) function in atopic dermatitis (AD) children skin is double-handed: an infectious trigger and an allergen. The study was aimed to evaluate a frequency of S. aureus enterotoxins IgE work out in children with infected AD skin and to compare IgE levels with infected AD severity. Methods. Specific IgE to S. aureus enterotoxins A and B (ImmunoCap, Phadia AB, Sweden) detected in serum of 90 children with infected AD. IgE levels were compared to severity of infected AD (Mann—Whitney Utest). Results. Specific IgE>0,35 kUA/l to S. aureus enterotoxin A frequency was of 0,29; to enteritoxin B 0,36; to one of them 0,43. IgE to S. aureus enterotoxins were elevated in 16 children with therapy resistant AD in compare to other cases of AD (р=0,00183). Conclusion. In children with infected AD S. aureus enterotoxins A or/and B are revealed in 25—50% of cases. In children with therapy resistant AD specific IgE level to enterotoxins is elevated in comparison to severe or average AD children.
作者简介
M Treneva
Federal State Institution «Moscow Research Institute of Pediatrics and Child Surgery» by Ministry of Health and Social Welfare of Russia
Email: trenevamarina@mail.ru
A Pampura
Federal State Institution «Moscow Research Institute of Pediatrics and Child Surgery» by Ministry of Health and Social Welfare of Russia
T Okuneva
Federal State Institution «Moscow Research Institute of Pediatrics and Child Surgery» by Ministry of Health and Social Welfare of Russia
参考
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