Local and systemic immune response in patients withsevere atopic dermatitis
- 作者: Filimonova TM1, Elisyutina O.G.1, Fedenko ES1, Niyazov DD1, Boldyreva MN1, Burmenskaya OV2, Rebrova OY.3, Filimonova TM4, Elisyutina OG4, Fedenko ES4, Niazov DD4, Boldyreva MN4, Burmenskaya OV5, Rebrova OY.6
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隶属关系:
- ФГБУ «ГНЦ И нститут иммунологии» ФМБА Р оссии
- ФГУ «Научный центр акушерства, гинекологии и перинатологииим. академика В .И. К улакова» М инздравсоцразвития Р оссии
- ГОУ ВПО РГМУ Росздрава
- Institute of Immunology
- Scientific Center for Obstetrics, Gynecology and Perinatology named after V.I. Kulakov
- Russian State Medical University
- 期: 卷 8, 编号 5 (2011)
- 页面: 10-15
- 栏目: Articles
- URL: https://ogarev-online.ru/raj/article/view/121099
- DOI: https://doi.org/10.36691/RJA771
- ID: 121099
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详细
dermatitis (AD) patients and healthy individuals.
Methods. Samples of skin and peripheral blood from 48 severe AD patients SCORAD (Scoring Atopic Dermatitis)
78,5 [57; 89], IGA (Investigators Global Assessment) 4,2 [3,9; 4,7]) at the age of 17 to 45 years and 20 healthy donors
aged from 19 to 32 years were analyzed for gene expression of cytokines using real time reverse transcription
polymerase chain reaction (RT-PCR).
Results. In the skin of patients with AD, a significant increase of the level of gene expression was observed for
interleukin IL2R (interleukin) (р=0,0023), IL5 (р=0,002), IL6 (р=0,0023), IL8 (р=0,01), IL12β (р=0,0023), IL10
(р=0,0023), IL23 (р=0,002), IL29 (р=0,0023), and TGFβ (transforming growth factor) (p=0,0023) as compared to
healthy individuals. In contrast, no difference between AD patients and healthy donors was detected with respect
to cytokine gene expression in the peripheral blood.
Conclusions. Activity of IL-2R, IL-8, IL-12β, IL-23, IL-29, and TGFβ that are markers of chronic inflammation
and Th1 immune response in severe AD and IL-5, IL-10 that are anti-inflammatory cytokines and markers of
Th2 response was predominant in the skin but not in the blood of AD patients.
作者简介
T Filimonova
ФГБУ «ГНЦ И нститут иммунологии» ФМБА Р оссииФГБУ «ГНЦ И нститут иммунологии» ФМБА Р оссии
Ol'ga Elisyutina
ФГБУ «ГНЦ И нститут иммунологии» ФМБА Р оссии
Email: el-olga@yandex.ru
ФГБУ «ГНЦ И нститут иммунологии» ФМБА Р оссии
E Fedenko
ФГБУ «ГНЦ И нститут иммунологии» ФМБА Р оссииФГБУ «ГНЦ И нститут иммунологии» ФМБА Р оссии
D Niyazov
ФГБУ «ГНЦ И нститут иммунологии» ФМБА Р оссииФГБУ «ГНЦ И нститут иммунологии» ФМБА Р оссии
M Boldyreva
ФГБУ «ГНЦ И нститут иммунологии» ФМБА Р оссииФГБУ «ГНЦ И нститут иммунологии» ФМБА Р оссии
O Burmenskaya
ФГУ «Научный центр акушерства, гинекологии и перинатологииим. академика В .И. К улакова» М инздравсоцразвития Р оссииФГУ «Научный центр акушерства, гинекологии и перинатологииим. академика В .И. К улакова» М инздравсоцразвития Р оссии
O Rebrova
ГОУ ВПО РГМУ РосздраваГОУ ВПО РГМУ Росздрава
T Filimonova
Institute of ImmunologyInstitute of Immunology
O Elisyutina
Institute of ImmunologyInstitute of Immunology
E Fedenko
Institute of ImmunologyInstitute of Immunology
D Niazov
Institute of ImmunologyInstitute of Immunology
M Boldyreva
Institute of ImmunologyInstitute of Immunology
O Burmenskaya
Scientific Center for Obstetrics, Gynecology and Perinatology named after V.I. KulakovScientific Center for Obstetrics, Gynecology and Perinatology named after V.I. Kulakov
O Rebrova
Russian State Medical UniversityRussian State Medical University
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