Sepsis in newborns (Draft federal guidelines)

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Neonatal sepsis is one of the most severe diseases of the neonatal period with a high probability of developing multiple organ dysfunction, septic shock and an unfavorable outcome. The purpose of this publication is to present draft federal clinical guidelines for the treatment of sepsis in newborns, which were developed taking into account the principles of evidence-based medicine. During the preparation of clinical guidelines, key questions were formulated using the PIPOH formula: P (population) — patient population and disease characteristics (neonate with sepsis and septic shock); I (interventions) — intensive care measures; P (professionals) — target audience of clinical recommendations (anesthesiologists, intensive care physicians, neonatologists, pediatricians, surgeons, infectious disease doctors); O (outcomes) — expected outcomes that can be improved (patient outcomes, health system indicators, epidemiological indicators, etc.); H (health care setting) — place of medical care (outpatient clinic, hospital, intensive care unit). The project includes sections on the etiology, pathogenesis and diagnosis of sepsis in newborns. Particular attention is paid to the issues of microbiological diagnostics, identification of the pathogen, antibacterial therapy, respiratory and nutritional support, extracorporeal hemocorrection, the use of intravenous immunoglobulins. It has been demonstrated that one of the mandatory elements of therapy is the early initiation of enteral nutrition using breast milk, the use of which is one of the most effective methods for the prevention of late sepsis in premature newborns with low and extremely low birth weight.

作者简介

Yuri Alexandrovich

Saint Petersburg State Pediatric Medical University

Email: Jalex1963@mail.ru
ORCID iD: 0000-0002-2131-4813
SPIN 代码: 2225-1630

MD, PhD, Dr. Sci. (Medicine), Professor, Head of the Department of Anesthesiology and Intensive Care and Emergency Pediatrics Postgraduate Education Saint Petersburg State Pediatric Medical University

俄罗斯联邦, Saint Petersburg

Ekaterina Balashova

Research Center for Obstetrics, Gynecology and Perinatology

Email: katbal99@gmail.com
ORCID iD: 0000-0002-3741-0770
SPIN 代码: 1335-1489

MD, PhD, Leading Researcher of the NICU named after Professor A.G. Antonov of the Institute of Neonatology and Pediatrics National Medical Research Center for Obstetrics, Gynecology and Perinatology named after Academician V.I. Kulakov of Ministry of Healthcare of Russian Federation, Associate Professor of the Department of Neonatology of the Institute of Professional Education National Medical Research Center for Obstetrics, Gynecology and Perinatology named after Academician V.I. Kulakov of Ministry of Healthcare of Russian Federation

俄罗斯联邦, Moscow

Irina Boronina

Voronezh State Medical University

Email: irinaboronina@bk.ru
ORCID iD: 0000-0003-2266-3297
SPIN 代码: 8900-0990

MD, PhD, Associate Professor, Head Dept of Anesthesiology and Resuscitation, Voronezh State Medical University named after N.N. Burdenko

俄罗斯联邦, Voronezh

Anna Zavyalova

Saint Petersburg State Pediatric Medical University

Email: anzavjalova@mail.ru
ORCID iD: 0000-0002-9532-9698
SPIN 代码: 3817-8267

MD, PhD, Dr. Sci. (Medicine), Professor, Department of Propaedeutics of Children's Diseases with a Course in General Child Care, Saint Petersburg State Pediatric Medical University

俄罗斯联邦, Saint Petersburg

Lyubov Zolotareva

Pirogov Russian National Research Medical University

Email: l_zolotareva@mail.ru
ORCID iD: 0000-0001-7662-8257
SPIN 代码: 4553-0869

MD, PhD, Senior Researcher, Department of Pediatric Reconstructive and Plastic Surgery, Institute of Motherhood and Childhood, Pirogov Russian National Research Medical University

俄罗斯联邦, Moscow

Dmitry Ivanov

Saint Petersburg State Pediatric Medical University

Email: spb@gpma.ru
ORCID iD: 0000-0002-0060-4168
SPIN 代码: 4437-9626

MD, PhD, Dr. Sci. (Medicine), Professor, Head of the Department of Neonatology with Courses in Neurology and Obstetrics-Gynecology Postgraduate Education Rector, Saint Petersburg State Pediatric Medical University

俄罗斯联邦, Saint Petersburg

Oleg Kirilochev

Astrakhan State Medical University

Email: kirilochevoleg@gmail.com
ORCID iD: 0000-0003-2821-7896
SPIN 代码: 5463-3997

MD, PhD, Dr. Sci. (Medicine), Assistant Professor, Head, Department of Anesthesiology and Resuscitation, Astrakhan State Medical University

俄罗斯联邦, Astrakhan

Ivan Lisitsa

Saint Petersburg State Pediatric Medical University

Email: ivan_lisitsa@mail.ru
ORCID iD: 0000-0003-3501-9660
SPIN 代码: 4937-7071

Assistant Professor, Department of General Medical Practice, Saint Petersburg State Pediatric Medical University

俄罗斯联邦, Saint Petersburg

Anastasiya Makulova

Pirogov Russian National Research Medical University; Children’s City Clinical Hospital No. 9 named after G.N. Speransky

Email: mak-ulova@mail.ru
ORCID iD: 0000-0001-9952-3159

MD, PhD, Head of the Center for Neonatal Nephrology and Dialysis, Children's City Clinical Hospital No. 9 named after G.N. Speransky of the Moscow Department of Health; Associate Professor of the Department of Pediatrics named after Academician M.Ya. Studenikin, Faculty of Medicine, Pirogov Russian National Research Medical University

俄罗斯联邦, Moscow; Moscow

Petr Mironov

Bashkortostan State Medical University

Email: mironovpi@mail.ru
ORCID iD: 0000-0002-9016-9461
SPIN 代码: 5617-6616

MD, PhD, Dr. Sci. (Medicine), Professor, of the Department of anesthesiology, Bashkortostan State Medical University

俄罗斯联邦, Ufa

Regina Osokina

Bakoulev Scientific Center for Cardiovascular Surgery

Email: raosokina@bakulev.ru
ORCID iD: 0009-0007-1513-2865
SPIN 代码: 9435-7723

Clinical Pharmacologist A.N. Bakulev National Medical Research Center for Cardiovascular Surgery

俄罗斯联邦, Moscow

Ekaterina Pavlovskaya

Saint Petersburg State Pediatric Medical University

Email: l.pavlovskaya@yandex.ru
ORCID iD: 0000-0001-9960-7141
SPIN 代码: 4308-6025

Assistant Professor, Department of Anaesthesiology, Reanimatology and Emergency Pediatrics, Saint Petersburg State Pediatric Medical University

俄罗斯联邦, Saint Petersburg

Dmitry Popov

Bakoulev Scientific Center for Cardiovascular Surgery

Email: dapopov@bakulev.ru
ORCID iD: 0000-0003-1473-1982
SPIN 代码: 6694-6714

MD, PhD, Dr. Sci. (Medicine), Professor of the Russian Academy of Sciences, Professor of the Department of Anesthesiology and Reanimatology with a Course of clinical Laboratory Diagnostics, head of the Microbiological (bacteriological) laboratory A.N. Bakulev, National Medical Research Center for Cardiovascular Surgery

俄罗斯联邦, Moscow

Konstantin Pshenisnov

Saint Petersburg State Pediatric Medical University

编辑信件的主要联系方式.
Email: Psh_K@mail.ru
ORCID iD: 0000-0003-1113-5296
SPIN 代码: 8423-4294

MD, PhD, Dr. Sci. (Medicine), Professor of Anesthesiology, Intensive Care and Emergency Pediatrics Postgraduate Education, Saint Petersburg State Pediatric Medical University

俄罗斯联邦, 2, Litovskaya st., Saint Petersburg, 194100

Vera Sergeeva

Kursk State Medical University

Email: verasergeeva1973@icloud.com
ORCID iD: 0000-0002-2947-2859

MD, PhD, Dr. Sci. (Medicine), Professor, Department of Anesthesia, Reanimation and Intensive Therapy, Kursk State Medical University

俄罗斯联邦, Kursk

Konstantin Serednyakov

Saint Petersburg State Pediatric Medical University

Email: spbny@yahoo.com
ORCID iD: 0000-0002-2213-0477
SPIN 代码: 1726-6155

MD, PhD, Assistant Professor, Departments of Anesthesiology, Intensive Care and Emergency Pediatrics of the Saint Petersburg State Pediatric Medical University

俄罗斯联邦, Saint Petersburg

Larisa Fedorova

Saint Petersburg State Pediatric Medical University

Email: arslarissa@rambler.ru
ORCID iD: 0000-0001-9747-762X
SPIN 代码: 5474-0902

MD, PhD, Associate Professor, Department of Neonatology with Сourses in Neurology and Obstetrics and Gynecology, Saint Petersburg State Pediatric Medical University

俄罗斯联邦, Saint Petersburg

Anna Agafonova

Saint Petersburg State Pediatric Medical University

Email: anna060bm@yandex.ru
ORCID iD: 0000-0002-2611-3949

Anesthesiology, Intensive Care and Emergency Pediatrics Department Resident Doctor, Saint Petersburg State Pediatric Medical University

俄罗斯联邦, Saint Petersburg

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