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发表评论 Proton magnetic resonance spectroscopy in children with delayed mental and speech development associated with focal temporal lobe epilepsy
- 作者: Sergeev A.M.1, Pozdnyakov A.V.1,2, Grechaniy S.V.1, Atamanova E.E.3, Pozdnyakova O.F.1,2,4, Shokin O.V.1,5, Polishchuk V.I.1
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隶属关系:
- St. Petersburg State Pediatric Medical University
- Academician A.M. Granov Russian Scientific Center of Radiology and Surgical Technologies
- Clinic “Doctrine”
- North-Western State Medical University named after I.I. Mechnikov
- I.P. Pavlov Institute of Physiology of the Russian Academy of Sciences
- 期: 卷 12, 编号 6 (2021)
- 页面: 27-34
- 栏目: Original studies
- URL: https://ogarev-online.ru/pediatr/article/view/106309
- DOI: https://doi.org/10.17816/PED12627-34
- ID: 106309
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详细
Background. The delays in mental and speech development are caused by epilepsy, and a special place among the forms of which is focal temporal epilepsy. The study of biomarkers of the considered pathological condition using proton magnetic resonance spectroscopy as indicators amenable to objective assessment and measurement determines the practical relevance of this work.
Aim. The aim of the study was to determine the role and place of proton magnetic resonance spectroscopy in clinical practice in children with mental and speech retardation associated with temporal lobe epilepsy.
Materials and methods. 37 children aged 2 to 10 years were studied. Of these, 15 children with a diagnosis of “mental and speech development delay, structural focal temporal epilepsy” were included in the first comparison group. The second comparison group consisted of 12 children without CNS pathology undergoing 1H-MRI examination to exclude somatic diseases. The third comparison group consisted of 10 children with “structural focal temporal epilepsy”, without mental and speech development delay.
Discussion. Multivoxel proton magnetic resonance spectroscopy (method PRESS) was used to determine the concentration of neurometabolites in the brain tissues of patients. In patients with mental and speech development delay associated with temporal epilepsy, a decrease in the ratio of NAA/Cr concentrations (p < 0.05) was revealed in the postcentral gyrus on the right, temporal lobe on the right and hippocampus and inner capsule on both sides, due to a decrease in the concentration of N-acetylaspartate; an increase in the ratio of Cho/Cr concentrations (p < 0.05) in the prefrontal cortex, postcentral gyrus and inner capsule on both sides, due to an increase in the concentration of choline. Two patients also showed lipid peaks on the lesion side when compared with EEG data.
Conclusions. The revealed metabolic changes in patients with delayed mental and speech development associated with temporal lobe epilepsy may be useful as an additional method of differential diagnosis with other forms of mental and speech development delay.
作者简介
Artur Sergeev
St. Petersburg State Pediatric Medical University
编辑信件的主要联系方式.
Email: artur5ergeeff@yandex.ru
Postgraduate Student, Department of Medical Biophysics
俄罗斯联邦, Saint PetersburgAlexander Pozdnyakov
St. Petersburg State Pediatric Medical University; Academician A.M. Granov Russian Scientific Center of Radiology and Surgical Technologies
Email: pozdnyakovalex@yandex.ru
MD, PhD, Dr. Med. Sci., Professor, Head of the Department of Radiation Diagnostics, Head of the Department of Medical Biophysics
俄罗斯联邦, Saint Petersburg; Saint PetersburgSeverin Grechaniy
St. Petersburg State Pediatric Medical University
Email: svgrechany@mail.ru
MD, PhD, Dr. Med. Sci, Associate Professor, Head of the Department of Psychiatry and Narcology
俄罗斯联邦, Saint PetersburgElina Atamanova
Clinic “Doctrine”
Email: atelel@mail.ru
MD, PhD, Cand. Sci. (Med.), neurologist, vertebrologist
俄罗斯联邦, Saint PetersburgOlga Pozdnyakova
St. Petersburg State Pediatric Medical University; Academician A.M. Granov Russian Scientific Center of Radiology and Surgical Technologies; North-Western State Medical University named after I.I. Mechnikov
Email: radiology@mail.ru
MD, PhD, Cand. Sci. (Med.), Associate Professor of the Department of Medical Biophysics, Radiologist of the Department of Radiation Diagnostics
俄罗斯联邦, Saint Petersburg; Saint Petersburg; Saint PetersburgOleg Shokin
St. Petersburg State Pediatric Medical University; I.P. Pavlov Institute of Physiology of the Russian Academy of Sciences
Email: radiology@mail.ru
Senior Lecturer of the Department of Medical Biophysics
俄罗斯联邦, Saint Petersburg; Saint PetersburgVladimir Polishchuk
St. Petersburg State Pediatric Medical University
Email: radiology@mail.ru
Senior lecturer of the Department of Medical Biophysics
俄罗斯联邦, Saint Petersburg参考
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