Development of a new conceptual platform in asthmology. EAACI 2018
- Authors: Nesterenko Z.V.1, Bulatova E.M.1, Lagno O.V.1
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Affiliations:
- St. Petersburg State Pediatric Medical University, Ministry of Healthcare of the Russian Federation
- Issue: Vol 10, No 4 (2019)
- Pages: 103-110
- Section: Congresses’ and conferences’ reports
- URL: https://ogarev-online.ru/pediatr/article/view/18559
- DOI: https://doi.org/10.17816/PED104103-110
- ID: 18559
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Abstract
Asthma remains one of the most important medical and social problems of current medicine. Despite significant approaches the increase in its incidence continues. 334 million people worldwide are affected by this chronic disease and more than 250 thousand die every year. Current asthma treatment methods aren’t useful to achieve asthma control in half of patients that associates with high risk of exacerbation of the disease. Modern asthma management requires a deep analysis of the factors responsible for the asthma progression and the development of exacerbations. The European Academy of Allergology and Clinical Immunology was held May 26-30, 2018 in Munich. The present publication sums up speeches of leading experts in the field of allergology and clinical immunology. Well-known experts in the field of diagnostics, treatment, prevention of bronchial asthma, modern views on the problem, a common pathology, which, despite considerable efforts, continues to grow, especially in the children’s population. The use of recent advances in molecular allergology, clinical immunology makes it possible to convincingly prove the heterogeneity of bronchial asthma, the need to use new diagnostic and therapeutic methods: biomarkers to detect pheno-endotypic diseases with the appointment of strictly targeted individualized treatment of patients with the results of new biologics. All attention was paid to the study of emerging and clinical trends of uncontrolled bronchial asthma, proposals for the use of new classification structures with indication of biological markers of each pheno-endotype of uncontrolled bronchial asthma were considered. A revised version of the GINA with the revision of therapeutic tactics, including in children, is presented. The latest EAACI Congress made a significant contribution to improving the diagnosis and effective treatment of bronchial asthma, which will allow treating patients with different clinical manifestations of this disease.
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##article.viewOnOriginalSite##About the authors
Zoia V. Nesterenko
St. Petersburg State Pediatric Medical University, Ministry of Healthcare of the Russian Federation
Author for correspondence.
Email: zovas@mail.ru
MD, PhD, Dr Med Sci, Professor, Department of Propaedeutics of Children’s Diseases
Russian Federation, 2, Litovskay street, Saint-Peterburg, 194100Elena M. Bulatova
St. Petersburg State Pediatric Medical University, Ministry of Healthcare of the Russian Federation
Email: bulatova2008@gmail.com
MD, PhD, Professor, Head of Department of Propaedeutics of Children’s Diseases
Russian Federation, 2, Litovskay street, Saint-Peterburg, 194100Olga V. Lagno
St. Petersburg State Pediatric Medical University, Ministry of Healthcare of the Russian Federation
Email: Olga1526@yandex.ru
MD, PhD, Department of Propaedeutics of Children’s Diseases
Russian Federation, 2, Litovskay street, Saint-Peterburg, 194100References
- Agache I, Akdis C, Jutel M, Virchow JC. Untangling asthma phenotypes and endotypes. Allergy. 2012;67(7):835-846. https://doi.org/10.1111/j.1398-9995.2012.02832.x.
- Bisgaard H, Hermansen MN, Buchvald F, et al. Childhood asthma after bacterial colonization of the airway in neonates. N Engl J Med. 2007;357(15):1487-95. https://doi.org/10.1056/NEJMoa052632.
- Buels KS, Jacoby DB, Fryer AD. Non-bronchodilating mechanisms of tiotropium prevent airway hyperreactivity in a guinea-pig model of allergic asthma. Br J Pharmacol. 2012;165(5):1501-1514. https://doi.org/10.1111/j.1476-5381.2011.01632.x.
- Buhl R, Humbert M, Bjermer L, et al. Severe eosinophilic asthma: a roadmap to consensus. Eur Respir J. 2017;49(5). pii: 1700634. https://doi.org/10.1183/13993003.00634-2017.
- Charlson ES, Bittinger K, Haas AR, et al. Topographical continuity of bacterial populations in the healthy human respiratory tract. Am J Respir Crit Care Med. 2011;184(8):957-963. https://doi.org/10.1164/rccm.201104-0655OC.
- Chung KF, Wenzel SE, Brozek JL, et al. International ERS/ATS guidelines on definition, evaluation and treatment of severe asthma. Eur Respir J. 2014;43(2):343-73. https://doi.org/10.1183/09031936.00064614.
- Custovic A, Simpson A, Bardin PG, Le Souëf P. Allergy is an important factor in asthma exacerbation: a pro/con debate. Respirology. 2010;15(7):1021-1027. https://doi.org/10.1111/j.1440-1843.2010.01826.x.
- Dickson RP, Erb-Downward JR, Freeman CM, et al. Spatial variation in the healthy human lung microbiome and the adapted island model of lung biogeography. Ann Am Thorac Soc. 2015;12(6):821-830. https://doi.org/10.1513/AnnalsATS.201501-029OC.
- Gaga M, Zervas E, Gibson PG. Allergic and non-allergic factors in severe asthma. Eur Respir Mon. 2011;51: 107-19. https://doi.org/10.1183/1025448x. 10001210.
- Rothe T, Spagnolo P, Bridevaux PO, et al. Diagnosis and management of asthma – the swiss guidelines. Respiration. 2018;95(5):364-380. https://doi.org/10.1159/000486797.
- Hilty M, Burke C, Pedro H, et al. Disordered microbial communities in asthmatic airways. PLoS One. 2010;5(1): e8578. https://doi.org/10.1371/journal.pone.0008578.
- Kraft M, Cassell GH, Pak J, Martin RJ. Mycoplasma pneumoniae and Chlamydia pneumoniae in asthma: effect of clarithromycin. Chest. 2002;121(6):1782-8. https://doi.org/10.1378/chest.121.6.1782.
- Kuo CS, Pavlidis S, Loza M, et al. T-helper cell type 2 (Th2) and non-Th2 molecular phenotypes of asthma using sputum transcriptomics in U-BIOPRED. Eur Respir J. 2017;49(2). pii: 1602135. https://doi.org/10.1183/13993003.02135-2016.
- Martinez FD. Early-life origins of chronic obstructive pulmonary disease. N Engl J Med. 2016;375(9):871-8. https://doi.org/10.1056/NEJMra1603287.
- Moore WC, Fitzpatrick AM, Li X, et al. Clinical heterogeneity in the severe asthma research program. Ann Am Thorac Soc. 2013;10 Suppl: S118-124. https://doi.org/10.1513/AnnalsATS.201309-307AW.
- Wenzel S. Severe asthma: from characteristics to phenotypes to endotypes. Clin Exp Allergy. 2012;42(5):650-658. https://doi.org/10.1111/j.1365-2222.2011.03929.x.
- Wood LG, Baines KJ, Fu J, et al. The neutrophilic inflammatory phenotype is associated with systemic inflammation in asthma. Chest. 2012;142(1):86-93. https://doi.org/10.1378/chest.11-1838.
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