Prospective 5-year follow-up of patients with acute coronary syndrome and percutaneous coronary intervention
- Authors: Musikhina N.A.1, Teploukhova A.I.1, Petelina T.I.1, Gorbatenko E.A.1, Bessonov I.S.1, Gapon L.I.1
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Affiliations:
- Tyumen Cardiology Research Center, Tomsk National Research Medical Center of the Russian Academy of Sciences
- Issue: Vol 103, No 2 (2022)
- Pages: 181-187
- Section: Theoretical and clinical medicine
- URL: https://ogarev-online.ru/kazanmedj/article/view/79898
- DOI: https://doi.org/10.17816/KMJ2022-181
- ID: 79898
Cite item
Abstract
Background. The study of predictors that negatively affect the long-term prognosis of patients with an increased risk of coronary syndrome can improve the effectiveness of measures for the secondary prevention of cardiovascular events.
Aim. To determine the factors that have a negative impact on 5-year survival in patients with acute coronary syndrome and percutaneous coronary intervention.
Material and methods. 135 patients with acute coronary syndrome enrolled in the “Register of percutaneous coronary interventions” in 2012–2013 at the Tyumen Cardiology Center, a branch of the Tomsk Research Institute of Cardiology of the Russian Academy of Sciences, were included in the study. After 12 and 60 months, the clinical status of patients and ongoing drug therapy were evaluated, and an examination including echocardiography with an ultrasound scanner, daily monitoring of the electrocardiogram and standard blood pressure measuring was performed. Laboratory studies included general and biochemical blood tests. To calculate the factors associated with poor prognosis, a Cox proportional hazards regression model with stepwise inclusion was used. Survival was assessed by the Kaplan–Meier method using the Log-rank test (logarithmic test).
Results. After 1 year, only three-quarters of patients continued the recommended drug therapy, a similar trend continued after 5 years of follow-up. The number of patients without any antiplatelet therapy increased from 19.9% after 12 months to 29.7% after 60 months. Overall survival after 1 year was 97.1%, after 5 years — 86.7%. The risk of death increased in the presence of chronic kidney disease (risk ratio 15.1; 95% confidence interval 4.30–52.93; p=0.001); type 2 diabetes mellitus (risk ratio 3.67; 95% confidence interval 1.18–11.43; p=0.025), history of stroke (risk ratio 9.07; 95% confidence interval 1.85–44.60; p=0.007), in patients with a heart rate >80 beats per minute [risk ratio 4.3; (95% confidence interval 1.51–12.26; p=0.006) and at pulse pressure ≥60 mm Hg (risk ratio 4.68; 95% confidence interval 1.60–13.72; p=0.005)].
Conclusion. The predictors that influenced the 5-year survival of patients after acute coronary syndrome and percutaneous coronary intervention were chronic kidney disease, diabetes mellitus, a history of stroke, high pulse pressure, and increased heart rate of more than 80 beats per minute.
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##article.viewOnOriginalSite##About the authors
Natalia A. Musikhina
Tyumen Cardiology Research Center, Tomsk National Research Medical Center of the Russian Academy of Sciences
Author for correspondence.
Email: musihina@infarkta.net
ORCID iD: 0000-0002-8280-2028
SPIN-code: 9244-6574
Scopus Author ID: 6504001940
ResearcherId: AAX-2482-2020
M.D., Cand. Sci. (Med.), Head, Depart. of Emergency Cardiology, Scientific Depart. of Clinical Cardiology
Russian Federation, Tomsk, RussiaAlina I. Teploukhova
Tyumen Cardiology Research Center, Tomsk National Research Medical Center of the Russian Academy of Sciences
Email: teploukhova@infarkta.net
ORCID iD: 0000-0002-7268-3467
Scopus Author ID: 57220067896
ResearcherId: AAU-7756-2021
M.D., Junior Researcher, Head, Clinical Depart. No. 1
Russian Federation, Tomsk, RussiaTatyana I. Petelina
Tyumen Cardiology Research Center, Tomsk National Research Medical Center of the Russian Academy of Sciences
Email: petelina@infarkta.net
ORCID iD: 0000-0001-6251-4179
Scopus Author ID: 6507194861
ResearcherId: I-8913-2017
M.D., Doct. Sci. (Med.), Deputy Director for Scientific Work, Leading Researcher, Depart. of Arterial Hypertension and Coronary Insufficiency, Scientific Depart. of Clinical Cardiology
Russian Federation, Tomsk, RussiaElena A. Gorbatenko
Tyumen Cardiology Research Center, Tomsk National Research Medical Center of the Russian Academy of Sciences
Email: elena@infarkta.net
ORCID iD: 0000-0003-3675-1503
Scopus Author ID: 14045151200
ResearcherId: M-8298-2019
Junior Researcher, Laboratory of Instrumental Diagnostics, Scientific Depart. of Instrumental Research Methods
Russian Federation, Tomsk, RussiaIvan S. Bessonov
Tyumen Cardiology Research Center, Tomsk National Research Medical Center of the Russian Academy of Sciences
Email: bessonov@infarkta.net
ORCID iD: 0000-0003-0578-5962
Scopus Author ID: 35267911400
ResearcherId: E-3550-2014
Cand. Sci. (Med.), Head, Laboratory of X-ray endovascular methods of Diagnosis and Treatment, Scientific Depart. of Instrumental Research Methods
Russian Federation, Tomsk, RussiaLyudmila I. Gapon
Tyumen Cardiology Research Center, Tomsk National Research Medical Center of the Russian Academy of Sciences
Email: gapon@infarkta.net
ORCID iD: 0000-0002-3620-0659
Scopus Author ID: 7003891206
ResearcherId: S-6520-2016
M.D., Doct. Sci. (Med.), Prof., Head, Depart. of Clinical Cardiology
Russian Federation, Tomsk, RussiaReferences
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