电邮这篇文章 维生素A与妊娠-神话与现实，在子宫内膜异位症中的应用前景（文献综述）
- 作者: Seyidova C.I.1, Yarmolinskaya M.I.1,2
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隶属关系:
- The Research Institute of Obstetrics, Gynecology and Reproductology named after D.O. Ott
- North-Western State Medical University named after I.I. Mechnikov
- 期: 卷 70, 编号 6 (2021)
- 页面: 139-146
- 栏目: Reviews
- URL: https://ogarev-online.ru/jowd/article/view/72297
- DOI: https://doi.org/10.17816/JOWD72297
- ID: 72297
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详细
论证。视黄醇以其各种形式存在，是一种强大的抗氧化剂，对各种身体系统的功能有多方面的影响。只有当从外界获得维生素时，才能补充每日所需的维生素。过量摄入和缺乏视黄醇都与不良反应有关。
目的 — 评估维生素A在生殖系统功能中的作用、其对妊娠过程的影响，以及作为经病原学证实的子宫内膜异位症治疗的前景。
材料与方法。在2000年至2020年期间为了对文献数据进行回顾，我们分析了PubMed、ScienceDirect、 Cyberleninka等电子数据库中的文章。
结果和结论。维生素A在怀孕期间非常重要，它的缺乏与许多畸形的形成、呼吸窘迫综合征的发生和胎儿免疫系统的紊乱有关。尽管对孕妇使用维生素A的危险存在意见，但可以在计划阶段和怀孕期间以安全的治疗剂量（高达10,000 IU/天）开处方，以降低风险先天性畸形、阿普加评分较高的分娩、预防贫血。视黄醇具有抗增殖、抗肿瘤作用，影响雌激素的生物合成，这证明了其参与生殖器子宫内膜异位症发病机制的可能性。考虑到维生素A能够抑制子宫内膜样卵巢囊肿的增殖、减小子宫内膜样异位的大小、调节促炎细胞因子的合成，可以认为是治疗复杂性卵巢癌的一个有希望的方向。生殖器子宫内膜异位症。
作者简介
Chimnaz I. Seyidova
The Research Institute of Obstetrics, Gynecology and Reproductology named after D.O. Ott
Email: seidov_46@mail.ru
ORCID iD: 0000-0002-6800-8661
俄罗斯联邦, Saint Petersburg
Maria I. Yarmolinskaya
The Research Institute of Obstetrics, Gynecology and Reproductology named after D.O. Ott; North-Western State Medical University named after I.I. Mechnikov
编辑信件的主要联系方式.
Email: m.yarmolinskaya@gmail.com
ORCID iD: 0000-0002-6551-4147
SPIN 代码: 3686-3605
Scopus 作者 ID: 7801562649
Researcher ID: P-2183-2014
MD, Dr. Sci. (Med.), Professor, Professor of the Russian Academy of Sciences
俄罗斯联邦, Saint Petersburg参考
- Borisova EO. Naznachenie vitaminov vo vremja beremennosti. Lechebnoe delo. 2010;(3):20−29. (In Russ.)
- Viktorov AP, Vojtenko AG. Preparaty vitamina A v fokuse bezopasnosti. Provizor. 2008;(9) [cited 23 Aug 2021]. Available from: http://provisor.com.ua/archive/2008/N09/viktor_98.php?part_code=32&art_code=6552. (In Russ.)
- Mahova AA, Maximov ML. Correction of vitamin status in pregnant women. RMZh. 2014;(14):1014−1018. (In Russ.)
- Gromova OA, Torshin IYu. Vitamin A dosage in pregnancy. Voprosy ginekologii, akusherstva i perinatologii. 2010;9(2):86−95. (In Russ.)
- Dawson MI. The importance of vitamin A in nutrition. Curr Pharm Des. 2000;6(3):311−325. doi: 10.2174/1381612003401190
- Spirichev VB, Shatnjuk LN, Poznjakovskij VM. Obogashhenie pishhevyh produktov vitaminami i mineral’nymi veshhestvami. Novosibirsk: Sibirskoe medicinskoe izdatel’stvo; 2004. (In Russ.)
- Clagett-Dame M, Knutson D. Vitamin A in reproduction and development. Nutrients. 2011;3(4):385−428. doi: 10.3390/nu3040385
- Emel’janova TP. Vitaminy i mineral’nye veshhestva: Polnyj spravochnik dlja vrachej. Moscow; 2001. (In Russ.)
- Shamitova EN, Serebryakova AA, Jhukova AA. Vitamin A and its role in the human body. Mejdunarodniy studenceskiy nauchniy vestnik. 2019;(3):15−16. (In Russ.)
- Zinder R, Cooley R, Vlad LG. et al. Vitamin A and wound healing. Nutr Clin Pract. 2019;34(6):839−849. doi: 10.1002/ncp.10420
- Kawaguchi R, Yu J, Honda J, et al. A membrane receptor for retinol binding protein mediates cellular uptake of vitamin A. Science. 2007;315(5813):820−825. doi: 10.1126/science.1136244
- Gutierrez-Mazariegos J, Schubert M, Laudet V. Evolution of retinoic acid receptors and retinoic acid signaling. Subcell Biochem. 2014;70:55−73. doi: 10.1007/978-94-017-9050-5_4
- D’Ambrosio DN, Clugston RD, Blaner WS. Vitamin A metabolism: an update. Nutrients. 2011;3(1):63−103. doi: 10.3390/nu3010063
- Johnson EJ, Russell RM. Beta-Carotene. In: Encyclopedia of dietary supplements. 2nd ed. London: Informa Healthcare; 2010. P. 115−120 [cited 23 Aug 2021]. Available from: https://ru.scribd.com/document/317250430/Encyclopedia-of-Dietary-Supplements-2nd-Ed-P-Coates-Et-Al-Informa-2010-WW
- Heel RC, Brogden RN, Speight TM, et al. Vitamin A acid: a review of its pharmacological properties and therapeutic use in the topical treatment of acne vulgaris. Drugs. 1977;14(6):401−419. doi: 10.2165/00003495-197714060-00001
- de Caminha MF, Batista Filho M, Fernandes TF, et al. Vitamin A supplementation during puerperium: systematic review. Rev Saude Publica. 2009;43(4):699−706. doi: 10.1590/s0034-89102009005000038
- Priyadarshani AMB. Insights of hypercarotenaemia: A brief review. Clin Nutr ESPEN. 2018;23:19−24. doi: 10.1016/j.clnesp.2017.12.002
- Gromova OA, Torshin IY, Tetruasvili NK, et al. Vitamin A in obstetrics: basic and clinical research. Meditsinskiy alphavit. 2019;1(1):2−10. (In Russ.). doi: 10.33667/2078-5631-2019-1-1(376)-59-69
- Normy fiziologicheskih potrebnostej v jenergii i pishhevyh veshhestvah dlja razlichnyh grupp naselenija v Rossijskoj Federacii. Metodicheskie rekomendacii MR 2.3.1.2432-08. Moscow: Federal’nyj centr gigieny i jepidemiologii Rospotrebnadzora; 2009 [cited 23 Aug 2021]. Available from: https://mihsosch.obr-tacin.ru/index.php/deyatelnost/pitanie/normativno-pravovaya-baza/638-mr-2-3-1-2432-08-normy-fiziologicheskikh-potrebnostej-v-energii-i-pishchevykh-veshchestvakh. (In Russ.)
- Expert Council Resolution “An individualized approach to micronutrient pregnancy support”. Obstetrics and Gynecology. 2020;(11):248−250. (In Russ.). doi: 10.18565/aig.2020.11.248-250
- Ribeiro KDS, Araújo KF, Dimenstein R. Efeito da suplementação com vitamina A sobre a concentração de retinol no colostro de mulheres atendidas em uma maternidade pública. Rev Assoc Med Bras. 2009;55(4):452−457. doi: 10.1590/s0104-42302009000400022
- Bezerra DS, Araújo KF, Azevêdo GM, Dimenstein R. Maternal supplementation with retinyl palmitate during immediate postpartum period: potential consumption by infants. Rev Saude Publica. 2009;43(4):572−579. doi: 10.1590/s0034-89102009005000039
- Pierzchalski K, Taylor RN, Nezhat C, et al. Retinoic acid biosynthesis is impaired in human and murine endometriosis. Biol Reprod. 2014;91(4):84. doi: 10.1095/biolreprod.114.119677
- Yamagata Y, Takaki E, Shinagawa M, et al. Retinoic acid has the potential to suppress endometriosis development. J Ovarian Res. 2015;8:49. doi: 10.1186/s13048- 015-0179-6
- Kim JJ, Kurita T, Bulun SE. Progesterone action in endometrial cancer, endometriosis, uterine fibroids, and breast cancer. Endocr Rev. 2013;34(1):130−162. doi: 10.1210/er.2012-1043
- Li Y, Wang L, Ai W, et al. Regulation of retinoic acid synthetic enzymes by WT1 and HDAC inhibitors in 293 cells. Int J Mol Med. 2017;40(3):661−672. doi: 10.3892/ijmm.2017.3051
- Deng L, Shipley GL, Loose-Mitchell DS, et al. Coordinate regulation of the production and signaling of retinoic acid by estrogen in the human endometrium. J Clin Endocrinol Metab. 2003;88(5):2157−2163. doi: 10.1210/jc.2002-021844
- Vermot J, Fraulob V, Dollé P, et al. Expression of enzymes synthesizing (aldehyde dehydrogenase 1 and reinaldehyde dehydrogenase 2) and metabolizaing (Cyp26) retinoic acid in the mouse female reproductive system. Endocrinology. 2000;141(10):3638−3645. doi: 10.1210/endo.141.10.7696
- Lu H, Li S, Wu Q. Retinoic acid regulates endometriotic stromal cell growth through upregulation of Beclin1. Arch Gynecol Obstet. 2018;297(1):93−99. doi: 10.1007/s00404-017-4549-8
- Barra F, Ferrero S. The use of retinoic acid for the treatment of endometriosis. Arch Gynecol Obstet. 2018;298(1):231−232. doi: 10.1007/s00404-018-4774-9
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