The structure and risk factors of the postoperative cerebral dysfunction in oncosurgery
- 作者: Tsygan N.V.1, Yakovleva V.A.1, Ryabtsev A.V.1,2, Evtukhov S.I.1, Golokhvastov S.Y.1, Fufaev E.E.1, Dzidzava I.I.1, Litvinenko I.V.1
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隶属关系:
- S.M. Kirov Military Medical Academy
- B.P. Konstantinov Petersburg Institute of nuclear physics, National research center “Kurchatov Institute”
- 期: 卷 40, 编号 4 (2021)
- 页面: 43-50
- 栏目: Original articles
- URL: https://ogarev-online.ru/RMMArep/article/view/83621
- DOI: https://doi.org/10.17816/rmmar83621
- ID: 83621
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Aim of the research was to study the features of the structure of postoperative cerebral dysfunction, establishing the risk factors for the development of postoperative cerebral dysfunction and for the each of the clinical types during operations for malignant neoplasms of the chest and abdomen. The study was conducted in 2 stages: a retrospective study based on medical records and a prospective study. In a retrospective study by the method of directed selection from 93,129 clinical cases of patients, 47 cases of patients with acute stroke after surgery were selected. In prospective study, 102 patients (69 men, 33 women) aged 38 to 85 years were examined, the median age was 67 years. They were divided into two study groups: “thoracic”, “abdominal”. In a retrospective study, the incidence of perioperative stroke was 0.05%. In a prospective study of surgical operations for malignant neoplasms of the chest and abdomen, the incidence of postoperative cerebral dysfunction was 34%, perioperative stroke – 2%, symptomatic delirium of the early postoperative period – 11%, deferred cognitive impairment – 31%. Statistical processing of the prospective study data revealed 10 risk factors for postoperative cerebral dysfunction, 12 risk factors for perioperative stroke, 7 risk factors for symptomatic delirium of the early postoperative period, and 6 risk factors for deferred cognitive impairment. For each of the clinical types of postoperative cerebral dysfunction the Charlson comorbidity index has a significant predictive value, and therefore it seems appropriate to include this parameter in the preoperative examination algorithm (3 tables, bibliography: 8 refs)
作者简介
Nikolay Tsygan
S.M. Kirov Military Medical Academy
Email: 77tn77@gmail.com
ORCID iD: 0000-0002-5881-2242
SPIN 代码: 1006-2845
Scopus 作者 ID: 37066611200
Researcher ID: H-9132-2016
D.Sc. (Medicine), Associate Professor
俄罗斯联邦, Saint PetersburgVictoria Yakovleva
S.M. Kirov Military Medical Academy
Email: 24ro80@gmail.com
ORCID iD: 0000-0002-9839-3169
SPIN 代码: 6158-5505
Scopus 作者 ID: 210921-010693
Researcher ID: AAZ-6393-2021
俄罗斯联邦, Saint Petersburg
Aleksander Ryabtsev
S.M. Kirov Military Medical Academy;B.P. Konstantinov Petersburg Institute of nuclear physics, National research center “Kurchatov Institute”
Email: ryabtsev_av@pnpi.nrcki.ru
ORCID iD: 0000-0002-3832-2780
SPIN 代码: 9915-4960
Researcher ID: AAD-3948-2019
俄罗斯联邦, Saint Petersburg;
Leningrad region, Gatchina
Semen Evtukhov
S.M. Kirov Military Medical Academy
Email: evtukhoffs@gmail.com
ORCID iD: 0000-0002-9089-6837
SPIN 代码: 1170-2368
俄罗斯联邦, Saint Petersburg
Sergey Golokhvastov
S.M. Kirov Military Medical Academy
Email: golokhvastov@yandex.ru
ORCID iD: 0000-0001-5316-4832
SPIN 代码: 2515-2435
Scopus 作者 ID: 35795190600
Researcher ID: J-4237-2016
Ph.D. (Medicine)
俄罗斯联邦, Saint PetersburgEvgeniy Fufaev
S.M. Kirov Military Medical Academy
Email: fufaev.jj@gmail.com
SPIN 代码: 5758-2364
Ph.D. (Medicine), Associate Professor
俄罗斯联邦, Saint PetersburgIlya Dzidzava
S.M. Kirov Military Medical Academy
Email: dzidzava@mail.ru
ORCID iD: 0000-0002-5860-3053
SPIN 代码: 7336-9643
Scopus 作者 ID: 8901380100
Researcher ID: Q-1992-2016
D.Sc. (Medicine), Associate Professor
俄罗斯联邦, Saint PetersburgI. Litvinenko
S.M. Kirov Military Medical Academy
编辑信件的主要联系方式.
Email: litvinenkoiv@rambler.ru
ORCID iD: 0000-0001-8988-3011
SPIN 代码: 6112-2792
Researcher ID: F-9120-2013
D.Sc. (Medicine), Professor
俄罗斯联邦, Saint Petersburg参考
- Tsygan NV, Andreev RV, Ryabtsev AV, et al. Perioperative stroke and postoperative cerebral dysfunction in the surgical treatment of pathology of the valvular apparatus of the heart: epidemiology, pathogenesis features, treatment, prevention. In the Collective monograph: Gusev EI, Gekht AB, eds. Multidisciplinary Problems of Prevention and Treatment of Brain Diseases. Vol. 1. Moscow: Sam Polygraphist Publisher; 2019:77–102. (In Russ.)
- Tsygan NV, Trashkov AP, Andreev RV, et al. The incidence of postoperative cerebral dysfunction in coronary artery bypass grafting operations. In: Materials of the XI All-Russian Congress of Neurologists and the IV Congress of the National Association for Stroke Control. Neuroscience and Behavioral Physiology. 2019;119(5):492. (In Russ.)
- Peritogiannis V, Bolosi M, Lixouriotis C, Rizos DV. Recent Insights on Prevalence and Corelations of Hypoactive Delirium. Behav Neurol. 2015;2015:416792. doi: 10.1155/2015/416792
- Haller А. Le délire en unité de soins intensifs. Forum médical suisse. 2015;15(31–32): 696–701. (In France)
- Grazioli S, Paciaroni M, Agnelli G, et al. Cancer-associated ischemic stroke: A retrospective multicentre cohort study. Thromb Res. 2018;165:33–37. doi: 10.1016/j.thromres.2018.03.011
- Dardiotis E, Aloizou AM, Markoula S, et al. Cancer-associated stroke: Pathophysiology, detection and management (Review). Int J Oncol. 2019;54(3):779–796. doi: 10.3892/ijo.2019.4669
- Kryukov EV, Panevin TS, Popova LV. Age-related changes in the hemostasis system. Clinical Medicine (Russian Journal). 2020;98(1): 9–12. (In Russ.) doi: 10.34651/0023-2149-2020-98-1-9-12
- Allakhverdiev AK, Bagrova SG, Breder VV, et al. Clinical practice guidelines: Lung cancer. Available at: https://nop2030.ru/files/2019/08/025.pdf (accessed 25.03.2021). (In Russ.)
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