Email this article Molecular mechanisms of cell functioning in norm and pathology
- Authors: Tyukavin A.I.1, Suchkov S.V.2,3
-
Affiliations:
- Saint Petersburg State Chemical and Pharmaceutical University of the Ministry of Health of the Russian Federation
- Russian Biotechnological University of the Ministry of Science and Higher Education of the Russian Federation
- Moscow State Medical Dental University named after A. I. Evdokimov
- Issue: Vol 4, No 4 (2022)
- Pages: 26-40
- Section: Biomedical Sciences
- URL: https://ogarev-online.ru/PharmForm/article/view/132718
- DOI: https://doi.org/10.17816/phf227000
- ID: 132718
Cite item
Full Text
Abstract
In our study, the following are modern information about the structural and functional organization of cell membranes, the internal apparatus, as well as the cell organelle. The features of the functioning of the structural and dynamic genome are shown, including the main epigenetic mechanisms of gene expression regulation. The cell pathology section describes the main pathological processes that occur in cells after reversible and irreversible damage. The mechanisms and signaling pathways of the phenomenon, markers of cellular aging are highlighted, as well as the significance of this phenomenon in normal and pathological conditions. The main mechanisms of hypoxic and free-radical necrobiosis are described. The mechanisms, signaling pathways, and significance for the norm and pathology of two types of programmed cell death, autophagy and apoptosis, are discussed in detail. The prospect of using fundamental knowledge about the molecular mechanisms of life activity to improve the treatment of the most urgent types of pathology is shown.
Full Text
##article.viewOnOriginalSite##About the authors
Alexander I. Tyukavin
Saint Petersburg State Chemical and Pharmaceutical University of the Ministry of Health of the Russian Federation
Author for correspondence.
Email: alexander.tukavin@pharminnotech.com
SPIN-code: 8476-5366
Doctor of Medicine (MD), Professor, Head of the Department to Physiology and Pathology
Russian Federation, Saint PetersburgSergey V. Suchkov
Russian Biotechnological University of the Ministry of Science and Higher Education of the Russian Federation; Moscow State Medical Dental University named after A. I. Evdokimov
Email: ssuchkov57@gmail.com
SPIN-code: 7052-7335
Doctor of Medicine (MD), Professor, Chair of the Department of Personalized Medicine, Precision Nutriciology and Biodesign, Institute of Biotechnology & Global Health, Professor of the Department of Clinical Al-lergology and Immunology
Russian Federation, Moscow; MoscowReferences
- Physiology with the basics of anatomy: textbook / ed. A. I. Tyukavina, V. A. Chereshneva, V. N. Yakovleva, I. V. Gaivoronsky / Yu. V. Natochin, I. A. Narkevich, V. N. Yakovlev [and others]. – Moscow: Publishing House “Infra-M”, 2016. – 574 p. – ISBN 978-5-16-011002-8. (In Russ.).
- Patologija: Uch. / Pod red. Tjukavina A.I. – M.: NIC INFRA-M2020. – 844 s. – (VO: Specialitet)(P) (Tjukavin A. I. Vasil’ev A. G. Vlasov Timur Dmitrievich); Infra-M, 2020. (In Russ.).
- Clinical pathophysiology: Course of lectures / Edited by V. A. Chereshneva, P. F. Litvitsky, V. N. Gypsy. – 2nd edition, revised and enlarged. – St. Petersburg: SpecLit, 2015. – 472 p. – ISBN 978-5-299-00511-0. (In Russ.).
- Popov B. V. Introduction to the cell biology of stem cells: a teaching aid for students of biological and medical faculties of universities, as well as students of higher medical educational institutions / B. V. Popov; B.V. Popov. – St. Petersburg: SpecLit, 2010. – 319 p. – ISBN 978-5-299-00430-4. (In Russ.).
- Chereshnev V. A. Patologija. V 2-h tomah. Tom 1 / Pod red. V. A. Chereshneva, V. V. Davydova. – Moskva: GJeOTAR-Media, 2009. – 608 s. – ISBN 978-5-9704-0998-5. – Tekst: jelektronnyj // JeBS “Konsul’tant studenta”: [sajt]. – URL: https://www.studentlibrary.ru/book/ISBN9785970409985.html. (In Russ.).
- Patologija: uchebnik: v 2 t. / pod red. V. V. Davydova, V. A. Chereshneva. – 2-e izd., pererab. i dop. – Moskva : GJeOTAR-Media, 2023. – T. 2. – 664 s.: il. – doi: 10.33029/9704-6459-5-PDC2-2023-1-664. – ISBN 978-5-9704-6459-5. (In Russ.).
- Karbyshev M. S., Abdullaev Sh. P. Biohimija oksidativnogo stressa: uchebno-metodicheskoe posobie. FGBOU VO RNIMU imeni N.I. Pirogova Minzdrava Rossii, M.: Izdatel’stvo HH, 2018. 60 s. (In Russ.).
- Port K. M. Pathophysiology: basics / K. M. Port; K. Port; ed. G. V. Podryadina [i.e. Order]; [per. Koko reva E. V.]. – Moscow: Eksmo, 2011. – (Medicus Medica). – ISBN 978-5-699-43708-5. (In Russ.).
- Maltseva L. D. Pathology: Textbook / L. D. Maltseva, S. Ya. Dyachkova, E. L. Karpova. – Moscow: Limited Liability Company Publishing Group “GEOTAR-Media”, 2018. – 536 p. – ISBN 978-5-9704-4335-4. (In Russ.)
- Apoptoz v onkourologii / I. V. Knjaz’kin, V. N. Cygan; Rossijskaja akad. estestvennyh nauk, Sankt-Peterburgskij centr prostatologii. – Sankt-Peterburg: Nauka, 2007. – 239 s.: il., tabl.; 21 sm.; ISBN 978-5-02-026277-5. (In Russ.)
Supplementary files
