The development of antibiotic resistance of the probiotic strain Lactiplantibacillus plantarum 8P-A3 is associated with changes in the structure of extracellular vesicules and the character of their effect on bacterial biofilms

O. A. Chernova; Чернова О. А.; A. R. Kayumov; Каюмов А. Р.; M. I. Markelova; Маркелова М. И.; V. V. Salnikov; Сальников В. В.; M. P. Kutyreva; Кутырева М. П.; A. A. Khannanov; Ханнанов А. А.; M. S. Fedorova; Федорова М. С.; D. E. Zhuravleva; Журавлева Д. Э.; N. B. Baranova; Баранова Н. Б.; D. A. Faizullin; Файзуллин Д. А.; Y. F. Zuev; Зуев Ю. Ф.; V. M. Chernov; Чернов В. М.

doi:10.31857/S2686738924060059

The development of antibiotic resistance of the probiotic strain Lactiplantibacillus plantarum 8P-A3 is associated with changes in the structure of extracellular vesicules and the character of their effect on bacterial biofilms

作者: Chernova O.A.¹, Kayumov A.R.², Markelova M.I.¹^,2, Salnikov V.V.¹, Kutyreva M.P.², Khannanov A.A.², Fedorova M.S.², Zhuravleva D.E.², Baranova N.B.¹^,2, Faizullin D.A.¹, Zuev Y.F.¹, Chernov V.M.¹
隶属关系:
1. Kazan Institute of Biochemistry and Biophysics of Kazan Science Centre of the Russian Academy of Science
2. Kazan Federal University
期: 卷 519, 编号 1 (2024)
页面: 35-41
栏目: Articles
URL: https://ogarev-online.ru/2686-7389/article/view/274305
DOI: https://doi.org/10.31857/S2686738924060059
ID: 274305

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For the first time, it was shown that the development of resistance to antibiotics (amoxicillin and clarithromycin) in vitro in the probiotic strain Lactiplantibacillus plantarum 8p-a3, associated with large-scale genomic rearrangements, a change in the profile of phenotypic sensitivity to antimicrobials of different groups, and the evolution of virulence, is also accompanied by significant changes in the lactobacillus-derived extracellular membrane vesicles transferring lipids, polysaccharides, proteins, and nucleic acids. The changes are related to the structure and cargo of vesicles, as well as their activity against biofilms of opportunistic bacteria. The data obtained are relevant for understanding the molecular mechanisms of survival of microorganisms under the selective pressure of antimicrobials, the functional potential of the probiotic vesicles and assessing their safety.

关键词

probiotic bacteria, antibiotic resistance, extracellular vesicles, structure and function, proteome, bacterial biofilms

参考

Gill S., Catchpole R., Forterre P. // FEMS Microbiol. Rev. 2019. V. 43,3. P. 273–303.
Kim W., Lee E. J., Bae I. H., et al. // J. Extracell. Vesicles. 2020. V. 9,1. P. 1793514.
Charpentier L.A., Dolben E.F., Hendricks M.R., et al. // Membranes. 2023. V. 13,9. P. 752.
Dominguez Rubio A.P., D’Antoni C.L., Piuri O.E., et al. // Front. microbiol. 2022. V. 13. P. 864720.
Krzyzek P., Marinacci B., Vitale I., et al. // Pharmaceutics. 2023. V. 15,2. P. 522.
da Silva Barreira D., Laurent J., Lourenco J., et al. // Sci. Rep. 2023. V. 13,1. P. 1163.
Mancino W., Lugli G. A., van Sinderen D., et al. // Microorganisms. 2019. V. 7,12. P. 638.
Tardy L., Giraudeau M., Hill G. E., et al. // Proc. Natl. Acad. Sci. USA. 2019. V. 116,34. P. 16927–16932.
Card K.J., Thomas M.D., Graves Jr.J.L., et al. // Proc. Natl. Acad. Sci. USA. 2019. V.118,5. P. e2016886118.
Chernova O.A., Chernov V.M., Mouzykantov A.A., et al. // Int. J. Antimicrob. Agents. 2021. V. 57,2. P. 106253.
Kostenko V.V., Mouzykantov A.A., Baranova N.B., et al. // Microbiol. Spectr. 2022. V. 10,3. P. e0236021.
Chernov V.M., Chernova O.A., Mouzykantov A.A., et al. // Sci. World J. 2011. V. 11. P. 1120–1130.
Burmatova A., Khannanov A., Gerasimov A., et al. // Polymers. 2023. V. 15,15. P. 3248.
Zucchiatti P., Mitri E., Kenig S., et al. // Anal. Chem. 2016. V. 88,24. P. 12090–12098.
Chernov V.M., Mouzykantov A.A., Baranova N.B., et al. // J. Proteom. 2014. V. 110. P. 117–128.
Baidamshina D.R., Trizna E.Y., Holyavka, M.G., et al. // Sci. Rep. 2017. V.7. P. 46068
Hobby C.R., Herndon J.L., Morrow C.A., et al. // Microbiologyopen. 2019. V. 8,2. P. e00635.
Bai Y., Luo B., Zhang Y., et al. // Int. J. Biol. Macromol. 2021. V.185. P.1036–1049.
Slavetinsky С., Hauser J., Cordula Gekeler C., et al. // eLife . 2022. 11:e66376.
Arias-Rojas A, Arifah A, Angelidou G., et al. // PLoS Pathog. 2024. V.20,8. P. e1012462.

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卷 520, 编号 1 (2025)

The development of antibiotic resistance of the probiotic strain Lactiplantibacillus plantarum 8P-A3 is associated with changes in the structure of extracellular vesicules and the character of their effect on bacterial biofilms

全文:

详细

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作者简介

O. Chernova

A. Kayumov

M. Markelova

V. Salnikov

M. Kutyreva

A. Khannanov

M. Fedorova

D. Zhuravleva

N. Baranova

D. Faizullin

Y. Zuev

V. Chernov

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