Analgesic activity of the low molecular weight neurotrophin-3 dipeptide mimetic GTS-301
| Dublin Core | PKP Metadata Items | Metadata for this Document | |
| 1. | Title | Title of document | Analgesic activity of the low molecular weight neurotrophin-3 dipeptide mimetic GTS-301 |
| 2. | Creator | Author's name, affiliation, country | L. G. Kolik; FSBSI “Federal Research Center for Innovator and Emerging Biomedical and Pharmaceutical Technologies”; Russian Federation |
| 2. | Creator | Author's name, affiliation, country | M. A. Konstantinopolsky; FSBSI “Federal Research Center for Innovator and Emerging Biomedical and Pharmaceutical Technologies”; Russian Federation |
| 2. | Creator | Author's name, affiliation, country | N. M. Sazonova; FSBSI “Federal Research Center for Innovator and Emerging Biomedical and Pharmaceutical Technologies”; Russian Federation |
| 2. | Creator | Author's name, affiliation, country | A. D. Durnev; FSBSI “Federal Research Center for Innovator and Emerging Biomedical and Pharmaceutical Technologies”; Russian Federation |
| 2. | Creator | Author's name, affiliation, country | T. A. Gudasheva; FSBSI “Federal Research Center for Innovator and Emerging Biomedical and Pharmaceutical Technologies”; Russian Federation |
| 3. | Subject | Discipline(s) | |
| 3. | Subject | Keyword(s) | NT-3; low molecular weight mimetic; dipeptide; GTS-301; analgesia; rats |
| 4. | Description | Abstract | It was previously shown that the original dipeptide mimetic of the 4th loop neurotrophin-3 (NT-3) hexamethylenediamide bis-(N-monosuccinyl-L-asparaginyl-L-asparagine) (GTS-301), like full-size neurotrophin, predominantly activates the tyrosine kinase receptor TrkC and has a neuroprotective effect in vitro at concentrations of 10-5-10-12 M, as well as after systemic administration on rodents – antidiabetic (0.1 and 0.5 mg/kg) and antidepressant (5 and 10 mg/kg) effects. In this work, the analgesic properties of GTS-301 were identified, which were manifested in the dose range of 0.01-10 mg/kg after acute intraperitoneal injection to rats in the “tail flick” test. Dipeptide GTS-301 increased the threshold of pain response by 20-30% and the effect persisted for at least 24 hours after administration. |
| 5. | Publisher | Organizing agency, location | The Russian Academy of Sciences |
| 6. | Contributor | Sponsor(s) |
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| 7. | Date | (DD-MM-YYYY) | 11.04.2025 |
| 8. | Type | Status & genre | Peer-reviewed Article |
| 8. | Type | Type | Research Article |
| 9. | Format | File format | |
| 10. | Identifier | Uniform Resource Identifier | https://ogarev-online.ru/2686-7389/article/view/287125 |
| 10. | Identifier | Digital Object Identifier (DOI) | 10.31857/S2686738925010166 |
| 10. | Identifier | eLIBRARY Document Number (EDN) | tcgjna |
| 11. | Source | Title; vol., no. (year) | Doklady Rossijskoj akademii nauk. Nauki o žizni; Vol 520, No 1 (2025) |
| 12. | Language | English=en | ru |
| 13. | Relation | Supp. Files |
Fig. 1. Structure of the dimeric dipeptide mimetic NT-3 (compound GTS-301) (82KB) Fig. 2. Effect of GTS-301 on the latency period of reaction in rats in the tail-flick test Note: *, ** – p<0.05, p<0.01 compared to the control group in the corresponding time period; the number of animals in each group was 8; data are presented as Mean±S.E.M. (148KB) |
| 14. | Coverage | Geo-spatial location, chronological period, research sample (gender, age, etc.) | |
| 15. | Rights | Copyright and permissions |
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