Открытый доступ
Доступ предоставлен
Только для подписчиков
Том 6, № 3 (2016)
- Год: 2016
- Статей: 3
- URL: https://ogarev-online.ru/2634-8276/issue/view/13564
Article
Occurrences, mechanism of action, structural activity relationship and various pharmacological activities of thiadiazole and their derivatives
Аннотация
In the recent times, many people around the world are suffering drug resistant in most of the antibiotics used in different circumferences. In order to overcome the antibiotic resistance problem, there is need to use of existing antibiotics consciously and prepare novel compounds which exhibit high therapeutic profile against different pathogens with least resistance. In this review we discussed the thiadiazole derivatives and their different biological activities such as anti-inflammatory, anti-helicobacter pylori, anti-microbial, anti-cancer, antiviral, anti-depressant, analgesic, herbicidal and adenosine A3 receptor inhibitor, besides that this review also provides a detailed information about structural activity relationship (SAR) of such a compounds prepared by different medicinal chemist to date. In general, SAR is the smartest tool among the medicinal chemist to create a better therapeutic efficacy and high safety bioactive molecule in a short span of time. Besides that, we pointed out here different challenges of thiadiazole derivatives and its feature perspectives.
177-217
Analogies between chemical and biological processes occurring in autowave mode
Аннотация
On the examples of frontal polymerization, tumor growth, and propagation of the nerve impulse, we examined nonlinear phenomena in chemistry and biology. The results of theoretical and experimental studies on the loss of stability of thermal waves of frontal polymerization were presented. The stationarity loss limits for the reactions of epoxide resin curing, polymerization of metal-containing acrylamide complexes, and copolymerization of methyl methacrylate and styrene in the presence of single-walled nanotubes were experimentally studied and theoretically calculated. It was shown that stability of the frontal process waves depends on the heat balance of the exothermic polymerization reaction. Nonlinear phenomena at variation of the polymerization kinetic parameters were studied. The limits of the transition from stationary to nonstationary mode were determined on the basis of experimental data and theoretical calculations. Theoretical study of a diffusion-kinetic model of tumor growth was discussed; the wave nature of the propagation of tumors was shown. The FitzHugh–Nagumo model was studied in view of the diffusion equation; the possibility of formation of the oscillatory modes during the nerve impulse propagation was demonstrated.
218-251
Determination of cholesterol in blood. Part 3
Аннотация
The chronological development of procedures for determining the concentration of cholesterol in plasma, serum, and whole blood is presented in the review. It is stated that, since the correlation between the risk of development of cardiovascular diseases and the concentrations of total cholesterol, low-density lipoprotein cholesterol, and high-density lipoprotein cholesterol in human blood has been established by numerous medical studies, procedures for the measurement of these parameters have been developed most actively. A brief overview of these procedures and the results of their comparative tests in medical examinations of patients are given. Classifications are also proposed for procedures that determining total cholesterol, low-density lipoprotein cholesterol, and high-density lipoprotein cholesterol in blood. The mechanism of action of the chemical reactions taking place in these procedures, the advantages and disadvantages, and prioritization of the field of their application are considered. Promising directions in the development and improvement of procedures are mentioned, ensuring more accurate measurements of the blood cholesterol concentration, and alternative means of determining cardiovascular disease risk are discussed.
252-329