Email this article The spectrum of sensitization in infants with atopic dermatitis and its relationship with the severity of the disease
- Authors: Migacheva NB1
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Affiliations:
- Самарский государственный медицинский университет
- Issue: Vol 14, No 1-2 (2014)
- Pages: 118-122
- Section: Articles
- URL: https://ogarev-online.ru/2410-3764/article/view/24512
- DOI: https://doi.org/10.17816/2072-2354.2014.0.1-2.118-122
- ID: 24512
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Abstract
The aim of our study was to describe the spectrum of sensitization in infants with atopic dermatitis (AD) and to assess its relationship with the severity of disease. 62 young children aged from 10 to 36 months with mild to severe AD were included into the study. Sensitization was detected by measurement of specific IgE antibodies (ImmunoCAP, Sweden). Sensitization was determined in 51 AD infants (82,2%): 40 patients (64,5%) were sensitized to food allergens, 36 (61,2%) - to aeroallergens, 26 (41,9%) - to both food and inhalant allergens. Statistical analysis has revealed the strong positive association between severity of AD and sensitization to aeroallergens (molds, pollen, and animal dander).
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References
- Аллергия у детей: от теории к практике / под ред. Л. С. Намазовой-Барановой. М.: Союз педиатров России, 2010-2011. 668 с.
- Детская аллергология. Руководство для врачей / под ред. А.А. Баранова, И.И. Балаболкина. М., 2006. 688 с.
- Современные особенности атопического дерматита и бронхиальной астмы у детей: монография / Б.А. Шамов, Т.Г. Маланичева, С.Н. Денисова / под ред. А.Г. Шамовой. Казань: Медицина, 2010. 328 с.
- Шамов Б.А., Сафиуллина И.Г., Бешимова А.Б. Распространенность симптомов атопического дерматита и их взаимосвязь с респираторной аллергией у детей младшего школьного возраста // Казанский медицинский журнал. 2013. Т. 94, № 1. С. 55-59.
- Shen CY, Lin HK, Lin CH, Fu LS, Fu YC. The natural course of eczema from birth to age 7 years and the association with asthma and allergic rhinitis: a population-based cohort study // Allergy and Asthma Proceedings. 2013. Vol. 34(1):P. 78-83.
- Wollenberg A, Feichtner K. Atopic dermatitis and skin allergies - update and outlook // Allergy. 2013. Vol. 68(12). P. 1509-1519.
- Darlenski R, Kazandjieva J, Hristakieva E, Fluhr JW. Atopic dermatitis as a systemic disease // Clinical Dermatology. 2014. Vol. 32(3). P. 409-413.
- Benedictis FM, Franceschini F, Hill D, Naspitz C, Simons FE, Wahn U, Warner JO, de Longueville M; EPAAC Study Group. The allergic sensitization in infants with atopic eczema from different countries // Allergy. 2009. Vol. 64(2). P. 295-303.
- Moghtaderi M, Farjadian S, Kashef S, Alyasin S, Afrasiabi M, Orooj M. Specific IgE to common food allergens in children with atopic dermatitis // Iran Journal of Immunology. 2012. Vol. 9(1). P. 32-38.
- Cosićkić A, Skokić F, Colić-Hadzić B, Suljendić S, Hasanović E. Hypersensitivity to aeroallergens in children with atopic dermatitis // Acta Clinica Croatia. 2012. Vol. 51(4). P. 591-600.
- Dharmage SC, Lowe AJ, Matheson MC, Burgess JA, Allen KJ, Abramson MJ. Atopic dermatitis and the atopic march revisited // Allergy. 2014. Vol. 69(1). P. 17-27.
- Dhingra N, Gulati N, Guttman-Yassky E. Mechanisms of contact sensitization offer insights into the role of barrier defects vs. intrinsic immune abnormalities as drivers of atopic dermatitis // Journal of Investigating Dermatology. 2013. Vol. 133(10). P. 2311-2314.
- Boralevi F, Hubiche T, Léauté-Labrèze C, Saubusse E, Fayon M, Roul S, Maurice-Tison S, Taïeb A. Epicutaneous aeroallergen sensitization in atopic dermatitis infants - determining the role of epidermal barrier impairment // Allergy. 2008. Vol. 63(2). P. 205-210.
- Röckmann H, van Geel MJ, Knulst AC, Huiskes J, Bruijnzeel-Koomen CA, de Bruin-Weller MS. Food allergen sensitization pattern in adults in relation to severity of atopic dermatitis // Clinical and Translational Allergy. 2014. Vol. 28(4). P. 1-9.
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