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Introduction. The relevance of the study is due to the contradiction between the growing demands of pet owners for specialized infrastructure and the demands of other citizens for cleanliness and safety. The purpose of the work is to characterize the perception of urban environment problems by pet owners and other residents of Saransk, identify the main points of tension and suggest ways to overcome them.

Materials and methods. The empirical basis was compiled by a pilot questionnaire survey of Saransk residents conducted in May 2025 (n = 120). The sample is quota-based, representing the city's population over the age of 18 by gender and age. Data collection is an online survey. Pearson's χ2 criterion was applied to assess the statistical significance of differences in the responses of the groups.

Results. The assessment of the comfort of the environment, difficulties in owning animals, conflict practices, attitudes towards stray animals and measures to control their numbers were analyzed. It has been revealed that, despite the absence of massive open negativity, there is a hidden conflict potential associated with low awareness of existing infrastructure, non-compliance with walking rules and the perception of stray animals as a threat to safety.

Discussion and Conclusions. The study discusses ways to mitigate the dilemma through infrastructure development, educational work, and the involvement of both groups in urban planning, rule control, and support for humane programs to regulate the number of stray animals.

Introduction. Despite the recognition of the importance of process-oriented knowledge maps in knowledge management theory, the practical implementation of the tool is hindered by the lack of unified methods for their construction. The purpose of the article is to develop a categorical apparatus and a step-by-step methodology for constructing knowledge flows in the business processes of organizations.

Materials and methods. The theoretical basis consists of works on knowledge management, materials from the American Center for Productivity and Quality (APQC), as well as national standards of the Russian Federation. Methods of comparative analysis, categorization and modeling are applied.

Results. A methodology has been developed that visualizes the sources of knowledge directly on the business process diagram, which makes it possible to identify areas of duplication, loss and critical dependence on employees. A categorical apparatus is proposed that distinguishes the concepts of "knowledge owner", "knowledge repository", and "explicit/implicit knowledge".

Discussion and conclusion. The methodology specifies the general recommendations of the standards and reduces the risks of knowledge leakage. The materials are valuable for researchers and business analysts and can be integrated into knowledge management training courses.

Introduction. Modern linguistics demonstrates an increased interest in the semantic analysis of terms in various fields of activity. The study of English-language university terms is of great importance for understanding modern educational practices. This study aims to determine the semantic parameters of British university terms in a digital environment.

Materials and methods. The university terms presented on the official websites of leading universities in the UK were selected as empirical material. The total volume of the analyzed material amounted to 50 terminological units that partially belong to the noun. The method of content analysis is applied in order to detect the terms you are looking for, the analysis of dictionary definitions in order to verify their meanings, lexico-semantic classification in order to categorize them.

Results. The semantic classifications of English-language terms in the field of higher education are studied. The semantics of university terms on the websites of British universities is analyzed. A semantic classification of English-language university terms in the digital environment has been developed, which includes four thematic groups: organizational, methodological, professional, and academic terms. The frequency terms reproduced within the framework of organizational and academic groups are revealed.

Discussion and conclusion. The study expands knowledge about the lexical and semantic structure of university terms used on the websites of UK higher education institutions. The results obtained can be useful for studying English-language university terms in the framework of terminology and cultural linguistics.

Introduction. One of the most promising areas of a targeted approach to the treatment of malignant neoplasms is the inhibition of tubulin polymerization. In this regard, the aim of this study is the molecular design of new derivatives of combretastatin A-4 to identify compounds with high affinity for the colchicine site of β-tubulin.

Materials and methods. Molecular docking was performed in the Glide software package (Schrödinger Maestro module). The crystallographic structure of the tubulin-combretastatin A4 complex (PDB ID 5LYJ) was used as a receptor. To identify the structure–property relationships, the following descriptors were calculated: the number of hydroxyl and methoxyl groups; the presence of C=C bonds, cyclopropane and 1,2,5-oxadiazole rings. The ADME characteristics were calculated using the ADMETlab resource.

Results. Of the 96 compounds examined, 7 molecules demonstrated better (more negative) GlideScore values than combretastatin. The presence of methoxyl groups negatively correlates with the value of GlideScore, making the main contribution to affinity due to hydrophobic interactions with the binding site. Hydroxyl groups also contribute to improved binding to the target due to the formation of additional hydrogen bonds. Replacing the double bond with a cyclopropane fragment results in compounds with comparable affinity (GlideScore ≈ – 8.2 kcal/mol). In contrast, oxadiazole analogues, on average, exhibit worse binding rates.

Discussion and conclusion. Compounds containing a cis-alkene bridge and a combination of hydroxy and methoxy substituents demonstrated GlideScore values superior to combretastatin A-4, which makes them candidates for further synthesis and experimental study in vitro.

Introduction. Machine components contain parts made of non-ferrous metals and alloys, such as bronze. The surfaces of these parts wear out during operation, which leads to the need for their restoration. One of the most versatile and at the same time energy-efficient methods of restoring worn surfaces of parts is electric spark treatment. This process makes it possible to improve the operational properties of the parts, restoring their original dimensions. In this regard, the creation of electrodes from finely dispersed powdered materials is becoming an important direction. The purpose of the study is to develop a technology for manufacturing electrodes for electric spark processing based on powders obtained by electroerosion dispersion.

Materials and methods. Bronze powder BrKMc 3-1, obtained by electroerosion dispersion, was used for sintering. Sintering was carried out in the spark plasma sintering system SPS 10-3. For the preparation of samples and their subsequent analysis, the following were also involved: drying cabinet SHS-80-01 SPU, a set of sieves conforming to GOST 2715-75 standard, analytical scales of the Acculab ALC-210d4 brand and the Jingpu MX-2 X-ray fluorescence spectrometer.

Results. As a result of sintering, a billet with a diameter of 40 millimeters and a height of 20 millimeters was obtained. The chemical composition of the sintered electrodes is comparable to that of the original scrap metal. During trial welding, sintered bronze electrodes provided the formation of coatings that are not inferior in physico-mechanical and tribotechnical parameters to coatings obtained with a standard electrode material.

Discussion and conclusion. By the method of spark plasma sintering, it is possible to obtain electrodes from bronze powder materials obtained by electroerosion dispersion. These electrodes have properties suitable for their use in the process of electric spark processing.

Introduction. Breast cancer (BC) is the most common oncological pathology in women in Russia (23 % in the structure of oncological diseases). About 90 % of deaths from this disease are caused by metastases. In this regard, it is critically important to effectively detect metastases in the regional lymphatic system at the stage of tumor development. The aim of the study is to develop and present stratified variants of metastatic lesion of regional lymph nodes in breast cancer based on a comprehensive analysis of echographic semiotics, which are significant for optimizing the diagnostic algorithm.

Materials and methods. For the study, the results of a comprehensive examination of outpatient patients who applied for the first time and in dynamics to the Republican Oncological Dispensary in the period from August to November 2025 with a diagnosis of "malignant neoplasm of the mammary glands" were taken. The protocols of ultrasound examination of mammary glands, postoperative scars and regional lymph nodes were studied.

Results. Metastatic lymph node damage was detected in 14 (13 %) patients, including three at the initial treatment, 11 during dynamic follow–up, and two after radical mastectomy. Based on the analysis of echographic signs (shape, contours, internal structure, and the nature of blood flow), six variants of changes in lymph nodes were identified and characterized, of which five correspond to a metastatic lesion.

Discussion and conclusion. Due to the high incidence of breast cancer and polymophrism of echoscopic semiotics, any non-standard deviations in the structure of lymph nodes in women should be considered through the prism of the possibility of their metastatic lesion. Even if one of the criteria is present, it requires a comprehensive diagnosis and comparison with clinical data, mammography, and, above all, a biopsy (fine needle or trepanobiopsy). This contributes to the timely verification of breast cancer and the choice of rational treatment tactic.