Current methods of normalization and maintenance of mucous membranes in gynecology: A prospective study

Background. The study of the recovery and restoration of the mucous membranes of the genital tract with vaginal intimate gels is presented.

Aim. To determine the clinical effectiveness of special cosmetic gels for intimate hygiene, Floragel® and Vagizhenal® for restoration of the mucous membranes of the vulva and vagina.

Materials and methods. Two groups of women were formed, Floragel® and Vagizhenal®, to analyze the clinical efficacy of cosmetic gels for intimate hygiene. Group 1 included 30 women aged 25 to 55 with clinical symptoms of genital tract mucosa atrophic changes and the absence of normal vaginal microflora. For intimate hygiene, this group regularly used the gel for intimate hygiene Floragel® for 1 month. Group 2 included 30 women aged 25 to 55 with clinical symptoms of genital tract mucosa atrophic changes of various etiologies. For intimate hygiene, this group regularly used the gel for intimate hygiene Vagizhenal® for 1 month. The gels were applied regularly, two times a day in the morning and evening, in a thin layer after hygienic procedures. Evaluation of the clinical effectiveness of special cosmetic gels for intimate hygiene Floragel® and Vagizhenal® included assessment of clinical efficacy, indicators of gynecological status, findings of microscopic and microbiological examination of vaginal discharge (Femoflor system), determination of the vaginal health index, and measurement of nonspecific immune protection of the vagina – levels of interferon γ, interleukin (IL)-1β, IL-6, IL-10 in the vaginal discharge using enzyme-linked immunosorbent assay.

Results. As shown by the questionnaires and interviews with patients, the use of special cosmetic gels for intimate hygiene, Floragel® and Vagizhenal® was associated with a significant improvement (p<0.05) in clinical symptoms: an improvement of vaginal discharge, the disappearance of unpleasant odor and itching, and an improvement in the state of the vaginal mucous membranes and vulva. A special gynecological examination showed significant changes in the visual morphological and functional state characteristics of the vaginal mucosa and vulva. An improvement was reported in 90% (27) patients (p<0.05) who used Floragel® and in 80% (24) patients who used Vagizhenal®.

Conclusion. The results demonstrate Floragel® and Vagizhenal® gels' high efficiency in restoring normal microflora and moisturizing mucous membranes by optimizing microbiological indicators, improving the vaginal health index and local immunity factors, indicating that special gels for intimate hygiene Floragel® and Vagizhenal® have not only cosmetic but also therapeutic properties.