Email this article Use of a drug containing ornidazole-neomycin–prednisolone–econazole for the empirical treatment of vaginal infections
- Authors: Volkov V.G., Zakharova T.V.
- Issue: Vol 22, No 4 (2020)
- Pages: 28-32
- Section: ORIGINAL ARTICLE
- URL: https://ogarev-online.ru/2079-5831/article/view/43868
- DOI: https://doi.org/10.26442/20795696.2020.4.200304
- ID: 43868
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Abstract
Relevance. Empirical treatment of vaginitis is indicated due to its polymicrobial etiology and limited microbiological analysis. The aim of the study was to study the combination of ornidazole–neomycin–prednisolone–econazole (ONPE, Elzhina®) as a first-line drug for local treatment of patients with various forms of non-specific vaginitis.
Materials and methods. The study included 55 non-pregnant women aged 18 to 50 years (38±1.5 years) who had clinical and laboratory signs of acute vaginitis.
Results. All patients at the initial treatment complained of pathological discharge, 47 (85.5%) noted itching, burning, pain in the genital area of various degrees of severity, 17 (30.9%) – discomfort when urinating, 9 (16.4%) – unpleasant smell, 8 (14.5%) – dyspareunia, 4 (2.2%)– complained of sensations of a foreign body in the vagina. The clinical and laboratory effectiveness of treatment was 89.1% (49). In 6 (10.9%) patients, clinical improvement was noted, with the remaining laboratory signs of aerobic vaginitis.
Conclusion. The new combination of ornidazole–neomycin–prednisolone–econazole (ONPE, Elzhina® ) has a good efficacy and safety profile and can be used to initiate empirical treatment of non-specific inflammatory diseases of the lower genital tract.
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##article.viewOnOriginalSite##About the authors
Valerii G. Volkov
Author for correspondence.
Email: valvol@yandex.ru
ORCID iD: 0000-0002-7274-3837
D. Sci. (Med.), Tula State University
Russian FederationTatyana V. Zakharova
Email: valvol@yandex.ru
ORCID iD: 0000-0001-7716-0983
Cand. Sci. (Med.), Lazarev City Clinical Hospital №2
Russian FederationReferences
- Захарова Т.В. Бактериальный вагиноз и бактериальный вагинит: клинико-микробиологические варианты течения. Вестн. новых медицинских технологий. 2008; 15 (2): 192–4. [Zakharova T.V. Bacterial vaginosis and bacterial vaginitis: clinical and microbiological variants of the course. Vestnik novyh meditsinskih tehnologiy. 2008; 15 (2): 192–4 (in Russian).]
- Дикке Г.Б. Патологические выделения из влагалища: диагностика и лечение. Доктор.Ру. 2018; 6 (150): 26–9. doi: 10.31550/1727-2378-2018-150-6-26-29 [Dikke G.B. Diagnosis and Treatment of Abnormal Vaginal Discharge. Doctor.Ru. 2018; 6 (150): 26–9. doi: 10.31550/1727-2378-2018-150-6-26-29 (in Russian).]
- Захарова Т.В. Проблема оппортунистических инфекций влагалища у женщин репродуктивного возраста г. Тулы. Вестн. новых медицинских технологий. 2008; 15 (1): 199–200. [Zakharova T.V. Bacterial vaginosis and bacterial vaginitis: clinical and microbiological course options. Vestnik novyh meditsinskih tehnologiy. 2008; 15 (1): 199–200 (in Russian)]
- Sobel JD, Subramanian C, Foxman B et al. Mixed vaginitis-more than coinfection and with therapeutic implications. Curr Infect Dis Rep 2013; 15 (2): 104–8. doi: 10.1007/s11908-013-0325-5
- Кузнецова И.В. Бактериальный вагиноз и вульвовагинальный кандидоз: оптимальные схемы лечения больных с сочетанной инфекцией. Рос. вестн. акушера-гинеколога. 2013; 13 (3): 42–6. [Kuznetsova I.V. Bacterial vaginosis and vulvovaginal candidiasis: optimal treatment regimens for patients with co-infection. Russian Bulletin of the obstetrician-gynecologist. 2013; 13 (3): 42–6 (in Russian).]
- Işik G, Demirezen Ş, Dönmez HG, Beksaç MS. Bacterial vaginosis in association with spontaneous abortion and recurrent pregnancy losses. J Cytol 2016; 33 (3): 135–40. doi: 10.4103/0970-9371.188050
- Дикке Г.Б. Полимикробные ассоциации в этиологии воспалительных заболеваний половых органов у женщин. Акушерство и гинекология. 2017; 6: 151–8. doi: 10.18565/aig.2017.6.151-8 [Dikke G.B. Polimikrobnyye assotsiatsii v etiologii vospalitel’nykh zabolevaniy polovykh organov u zhenshchin. Akusherstvo i ginekologiya. 2017; 6: 151–8. doi: 10.18565/aig.2017.6.151-8 (in Russian).]
- Захарова Т.В., Волков В.Г. Опыт лечения бактериального вагиноза, ассоцированного с кандидозным вульвовагинитом. Акушерство и гинекология. 2016; 11: 131–5. doi: 10.18565/aig.2016.11.131-5 [Zakharova T.V., Volkov V.G. Experience in the treatment of bacterial vaginosis, associated with candidal vulvovaginitis. Obstetrics and Gynecology. 2016; 11: 131–5. doi: 10.18565/aig.2016.11.131-5 (in Russian).]
- Волков В.Г., Захарова Т.В. Оптимизация предоперационной подготовки женщин с цервикальными неоплазиями высокой степени. РМЖ. Мать и дитя. 2019; 2 (3): 243–6. doi: 10.32364/2618-8430-2019-2-3-243-246 [Volkov V.G., Zakharova T.V. Improving preoperative management of women with high-grade cervical intraepithelial neoplasia. Russian Journal of Woman and Child Health. 2019; 2 (3): 243–6. doi: 10.32364/2618-8430-2019-2-3-243-246 (in Russian).]
- Дмитрук В.С., Денисов А.А., Лушникова П.А. Современные возможности эффективного комбинированного лечения вульвовагинального кандидоза и бактериального вагиноза. Клин. дерматология и венерология. 2018; 17 (4): 65–70. DOI: 10.17116/ klinderma20181704165 [Dmitruk V.S., Denisov A.A., Lushnikova P.A Modern opportunities of effective combined treatment of vulvovaginal candidiasis and bacterial vaginosis. Russian Journal of Clinical Dermatology and Venereology. 2018; 17 (4): 65–70. doi: 10.17116/klinderma20181704165 (in Russian).]
- Кузьмицкая Е.В., Быковская Т.Ю., Доброрезова Ю.В. и др. Возможности использования комбинированного препарата местного действия для лечения вагинита с целью снижения риска развития патологии шейки матки на этапе постскрининговых мероприятий. РМЖ. 2017; 26: 1931–4. [Kuzmitskaya E.V., Bykovskaya T.Yu., Dobrorezova Yu.V. et al. The possibilities of using a topical combination drug for a treatment of vaginitis in order to reduce the risk of cervix pathology at the stage of postscreening activities. RMJ. 2017; 26: 1931–4 (in Russian).]
- Ткаченко Л.В., Вдовин С.В., Углова Н.Д. и др. Современное лечение вульвовагинитов у женщин репродуктивного возраста. Лекарственный вестник. 2018; 12 (3): 23–6. [Tkachenko L.V., Vdovin S.V., Uglova N.D. et al. Modern treatment of vulvovaginitis in women of reproductive age. Medicinal Bulletin. 2018; 12 (3): 23–6 (in Russian).]
- Малова И.О., Афанасьева И.Г., Гусевская К.А. Острые вагиниты смешанной этиологии: современный подход к лечению. Акушерство и гинекология: новости, мнения, обучение. 2019; 7 (4): 79–86. doi: 10.24411/2303-9698-2019-14007 [Malova I.O., Afanasieva I.G., Gusevskaya K.A. Acute vaginitis of mixed etiology: a modern approach to treatment. Obstetrics and Gynecology: News, Opinions, Training. 2019; 7 (4): 79–86. doi: 10.24411/2303-9698-2019-14007 (in Russian).]
- Соколова Т.М., Маринкин И.О., Кулешов В.М., Макаров К.Ю. Опыт применения нового комбинированного препарата для лечения урогенитальных инфекций Акушерство и гинекология: новости мнения, обучение. 2019; 7 (2): 68–72. doi: 10.24411/2303-9698-2019-12009 [Sokolova T.M., Marinkin I.O., Kuleshov V.M., Makarov K.Yu. Experience of applying the new combination drug for the treatment of urogenital of infections. Obstetrics and Gynecology: News, Opinions, Training. 2019; 7 (2): 68–72. doi: 10.24411/2303-9698-2019-12009 (in Russian).]
- Lowe NK, Neal JL, Ryan-Wenger NA. Accuracy of the clinical diagnosis of vaginitis compared with a DNA probe laboratory standard. Obstet Gynecol 2009; 113 (1): 89–95. doi: 10.1097/AOG.0b013e3181909f63
- Савичева А.М., Воробьева Н.Е., Вагорас А. и др. Использование метода прямой микроскопии урогенитальных мазков на амбулаторном приеме с целью оптимизации диагностики урогенитальных инфекций. Трудный пациент. 2008; 6 (1): 9–12. [Savicheva A.M., Vorobyova N. E., Vahoras A. et al. Using the method of direct microscopy of urogenital smears at outpatient admission in order to optimize the diagnosis of urogenital infections. Difficult patient. 2008; 6 (1): 9–12 (in Russian).]
- Seo SS, Arokiyaraj S, Kim MK et al. High Prevalence of Leptotrichia amnionii, Atopobium vaginae, Sneathia sanguinegens, and Factor 1 Microbes and Association of Spontaneous Abortion among Korean Women. Biomed Res Int 2017; 2017: 5435089. doi: 10.1155/2017/5435089
- Bretelle F, Chiarelli P, Palmer I, Glatt N. Prise en charge des infections vaginales après échec d’un traitement probabiliste : le prélèvement vaginal est-il réellement utile? [Management of vaginal infection following failure of a probabilistic treatment: is the vaginal swab really useful?]. Gynecol Obstet Fertil 2015; 43 (2): 139–43. doi: 10.1016/j.gyobfe.2014.12.007
- Landers DV, Wiesenfeld HC, Heine RP et al. Predictive value of the clinical diagnosis of lower genital tract infection in women. Am J Obstet Gynecol 2004; 190 (4): 1004–10. doi: 10.1016/j.ajog.2004.02.015
- Клинические рекомендации по диагностике и лечению заболеваний, сопровождающихся патологическими выделениями из половых путей женщин. М.: Российское общество акушеров-гинекологов, 2019. [Clinical recommendations for the diagnosis and treatment of diseases involving pathological secretions from the genital tract of women. Moscow: Russian Society of Obstetricians and Gynecologists, 2019 (in Russian).]
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