The occurrence of human papillomavirus types in the formation of neoplastic transformation of the epithelium of the cervix in “lesser abnormalies”

Aim. To assess the frequency of human papillomavirus (HPV) occurrence according to the IARC classification in patients with “lesser abnormalie” of cervical epithelial lesions and analyze their role in the formation of SIL.

Materials and methods. The study included 129 HPV-positive women aged 18–45 years (average age 34 to 11 years) with cytological conclusion NILM, ASCUS or LSIL. Patients are divided into 3 groups depending on the results of the cytological smear: 1 group (NILM/HPV) – 66 (51.2%), 2 group (ASCUS/HPV) – 28 (21.7%), 3 group (LSIL/HPV) – 35 (27.1%). During dynamic observation for 24 months. A comprehensive clinical-laboratory examination was carried out, including HPV-typing, cytological examination, extended colposcopy every 6 months, sighting biopsy of the cervix (according to the indications).

Results. According to the results of the pathomorphological study, squamous intraepithelial lesions neoplasia (cervical intraepithelial neoplasia – CIN+) was verified in 59 (71.9%) of the results of the study: LSIL (CIN I) – 53 (64.6%), HSIL (CIN II–III) – 6 (4.6%). The morphological diagnosis of LSIL (CIN I) was established in 1 group (NILM/HPV+) in 20 (55.6%), 2 groups (ASCUS/HPV+) – 9 (32%), 3 group (LSIL/HPV) – 24 (68.6%); HSIL (CIN II–III) in group 1 – 2 (5.6%), in 2 group – 3 (10.7%) and in the 3 group – 1 (2.9%).

Conclusions. In patients with “lesser abnormalies” of cervical lesions in the formation of CIN+ participated HPV group 1 – in 79.1%, groups 2A – in 5.5%, groups 2B – in 15.4% of cases. The HPV high carcinogenic risk (group 1) was involved in the formation of HSIL (CIN II–III). The neoplastic transformation of the cervical epithelium of the studied patients was caused by the persistence of HPV 16, 58, 39, 18, 51, 68, 56, 82, 35, 52, 53, 35 types.