Experience of the combined use of iron and folic acid preparations for the correction of latent iron deficiency in the clinical practice of an obstetrician-gynecologist. Clinical case
- Authors: Zefirova T.P.1, Mukhametova R.R.2, Khaertdinov A.T.2,3, Garipova E.M.4
-
Affiliations:
- Kazan State Medical Academy – branch of the Russian Medical Academy of Continuous Professional Education
- Kazan Federal University
- Kama Children's Medical Center
- Medical Diagnostic Center “Kazan Clinic”
- Issue: Vol 25, No 2 (2023)
- Pages: 262-266
- Section: CASE REPORT
- URL: https://ogarev-online.ru/2079-5831/article/view/134155
- DOI: https://doi.org/10.26442/20795696.2023.2.202223
- ID: 134155
Cite item
Full Text
Abstract
Iron deficiency anemia is widespread among the female population. Pregnant women are a particularly vulnerable group, because the existing iron reserves are inadequate, and during pregnancy the need for iron for the formation of the placenta and fetal growth increases sharply, as a result, there is an imbalance between the intake and consumption of this trace element. Anemia increases the risks of various complications of gestation and multiplies maternal mortality. Note an increase in the frequency of premature childbirth, the threat of termination of pregnancy, placental insufficiency, weakness of labor, fetal development delay, fetal hypoxia, low birth weight of the newborn, the volume of pathological blood loss during childbirth and in the early postpartum period. At the same time, the development of these pathological conditions can be prevented by following modern protocols of pre-pregnancy preparation and pregnancy management. Prevention of anemia includes the use of various iron preparations, as well as new combinations, in particular a combination of 80 mg of elemental iron and 350 mcg of folic acid. In the article, we describe clinical cases demonstrating a rational preventive approach that prevents the development of clinical anemia and promotes safe perinatal outcomes for mother and fetus.
Keywords
Full Text
##article.viewOnOriginalSite##About the authors
Tatiana P. Zefirova
Kazan State Medical Academy – branch of the Russian Medical Academy of Continuous Professional Education
Author for correspondence.
Email: tzefirova@gmail.com
ORCID iD: 0000-0001-6785-6063
D. Sci. (Med.)
Russian Federation, KazanRenata R. Mukhametova
Kazan Federal University
Email: tzefirova@gmail.com
ORCID iD: 0000-0002-7599-7998
Obstetrician-Gynecologist
Russian Federation, KazanAlbert T. Khaertdinov
Kazan Federal University; Kama Children's Medical Center
Email: tzefirova@gmail.com
ORCID iD: 0000-0001-6384-0507
Cand. Sci. (Med.)
Russian Federation, Kazan; Naberezhnye ChelnyEnzhe M. Garipova
Medical Diagnostic Center “Kazan Clinic”
Email: tzefirova@gmail.com
Obstetrician-Gynecologist
Russian Federation, KazanReferences
- Owais A, Merritt C, Lee C, Bhutta ZA. Anemia among Women of Reproductive Age: An Overview of Global Burden, Trends, Determinants, and Drivers of Progressin Low- and Middle-Income Countries. Nutrients. 2021;13(8):2745. doi: 10.3390/nu13082745
- Рекомендации ВОЗ по оказанию дородовой помощи для формирования положительного опыта беременности. Женева: Всемирная организация здравоохранения, 2017. Режим доступа: https://apps.who.int/iris/bitstream/handle/10665/251526/WHO-RHR-16.12. Ссылка активна на 13.03.2023 [WHO recommendations on antenatal care for a positive pregnancy experience. Geneva: WHO. Available at: https://apps.who.int/iris/bitstream/handle/10665/251526/WHO-RHR-16.12. Accessed: 13.03.2023 (in Russian)].
- Дикке Г.Б., Стуклов Н.И. Латентный дефицит железа и железодефицитная анемия у беременных. Алгоритмы диагностики и лечения. Фарматека. 2021;28(6):19-24 [Dikke GB, Stuklov NI. Latent iron deficiency and iron deficiency anemia in pregnant women. Diagnostic and treatment algorithms. Farmateka. 2021;28(6):19-24 (in Russian)]. doi: 10.18565/pharmateca.2021.6.19-24
- Milman NT. Dietary Iron Intake in Pregnant Women in Europe: A Review of 24 Studies from 14 Countries in the Period 1991–2014. J Nutr Metab. 2020;2020:7102190. doi: 10.1155/2020/7102190
- Jung J, Rahman MM, Rahman MS, et al. Effects of hemoglobin levels during pregnancy on adverse maternal and infant outcomes: a systematic review and meta-analysis. Ann N Y Acad Sci. 2019;1450(1):69-82. doi: 10.1111/nyas.14112
- Say L, Chou D, Gemmill A, et al. Global causes of maternal death: a WHO systematic analysis. Lancet Glob Health. 2014;2(6):e323-33. doi: 10.1016/S2214-109X(14)70227-X
- May-Panloup P, Boucret L, Chao de la Barca JM, et al. Ovarian ageing: the role of mitochondria in oocytes and follicles. Hum Reprod Update. 2016;22(6):725-43. doi: 10.1093/humupd/dmw028
- Rukuni R, Bhattacharya S, Murphy MF, et al. Maternal and neonatal outcomes of antenatal anemia in a Scottish population: a retrospective cohort study. Acta Obstet Gynecol Scand. 2016;95(5):555-64. doi: 10.1111/aogs.12862
- Shah HE, Bhawnani N, Ethirajulu A, et al. Iron Deficiency-Induced Changes in the Hippocampus, Corpus Striatum, and Monoamines Levels That Lead to Anxiety, Depression, Sleep Disorders, and Psychotic Disorders. Cureus. 2021;13(9):e18138. doi: 10.7759/cureus.18138
- Barks A, Fretham SJB, Georgieff MK, Tran PV. Early-Life Neuronal-Specific Iron Deficiency Alters the Adult Mouse Hippocampal Transcriptome. J Nutr. 2018;148(10):1521-8. doi: 10.1093/jn/nxy125
- Pavord S, Daru J, Prasannan N, et al. UK guidelines on the management of iron deficiency in pregnancy. Br J Haematol. 2020;188(6):819-30. doi: 10.1111/bjh.16221
- Куценко И.И., Кравцова Е.И., Холина Л.А., Томина О.В. Терапия латентного железодефицитного состояния у беременных. Гинекология. 2022;24(6):512-7 [Kutsenko II, Kravtsova EI, Kholina LA, Tomina OV. Latent iron deficiency therapy in pregnant women. Gynecology. 2022;24(6):512-7 (in Russian)]. doi: 10.26442/20795696.2022.6.202023
- Совет экспертов «Железодефицитные состояния у беременных: новая комбинация – новые возможности». Акушерство и гинекология: новости, мнения, обучение. 2021;9(4):79-82 [Expert council “Iron-deficiency conditions in pregnant women: new combination – new opportunities”. Obstetrics and Gynecology: News, Opinions, Training. 2021;9(4):79-82 (in Russian)].
Supplementary files
