Assessing trigeminal microstructure changes in patients with classical trigeminal neuralgia
- 作者: Rozhnova E.N.1, Dashyan V.G.1,2, Tokarev A.S.1, Evdokimova O.L.1, Neznanova M.V.1, Sinkin M.V.1,2
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隶属关系:
- N.V. Sklifosovsky Research Institute for Emergency Medicine
- A.I. Yevdokimov Moscow State University of Medicine and Dentistry
- 期: 卷 17, 编号 1 (2023)
- 页面: 20-26
- 栏目: Original articles
- URL: https://ogarev-online.ru/2075-5473/article/view/125983
- DOI: https://doi.org/10.54101/ACEN.2023.1.3
- ID: 125983
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Introduction. The crucial role of neuro-vascular conflict (NVC) in trigeminal neuralgia (TN) is getting increasingly challenged. Microstructural changes can be assessed using fractional anisotropy (FA) in diffusion tensor images (DTI).
Objective. To evaluate usefulness of FA in brain MRI with DTI for TN lateralization assessment.
Materials and methods. The study included 51 patients with classical TN divided into two groups: neurosurgical intervention free, post radiofrequency ablation (RFA), and a control group (patients without facial pain). All the patients were tested for NVC with FIESTA (Fast Imaging Employing Steady State Acquisition) brain MRI at 3Т. Difference in thickness of trigeminal roots on the intact and symptomatic sides was assessed for each group. The findings were compared to those in the control group. The MRI protocol was supplemented with DTI. The FA difference in thickness of the intact and symptomatic roots (∆FA) was calculated for each study group to assess microstructural root changes. The results were compared to those in the control group.
Results. In trigeminal root DTIs, ∆FA over 0.075 [0.029; 0.146] is statistically significant to establish NVC-associated microstructural changes on the symptomatic side in patients without any past surgeries (p = 0,030). In patients with a history of trigeminal ganglion RFA, statistically significant (p = 0.026) thinned symptomatic trigeminal root (difference in thickness of trigeminal roots over 0.45 cm [0.4; 0.6]) was found as compared to that of the control patients.
Conclusion. ΔFA may be used as a quantitative demyelination biomarker in clinical TN. Trigeminal ganglion RFA leads to hypotrophy throughout the trigeminal nerve root.
作者简介
Elizaveta Rozhnova
N.V. Sklifosovsky Research Institute for Emergency Medicine
编辑信件的主要联系方式.
Email: elizabett-eliz@yandex.ru
ORCID iD: 0000-0003-0521-4836
SPIN 代码: 1803-3451
Scopus 作者 ID: 57243798700
Neurologist
俄罗斯联邦, MoscowVladimir Dashyan
N.V. Sklifosovsky Research Institute for Emergency Medicine; A.I. Yevdokimov Moscow State University of Medicine and Dentistry
Email: v485@bk.ru
ORCID iD: 0000-0002-5847-9435
SPIN 代码: 7353-7768
Scopus 作者 ID: 56298034600
D. Sci. (Med.), Senior Researcher, Neurosurgeon. N.V. Sklifosovsky Research Institute of Emergency Medicine; Professor, A.I. Yevdokimov Moscow State University of Medicine and Dentistry
俄罗斯联邦, Moscow; MoscowAleksey Tokarev
N.V. Sklifosovsky Research Institute for Emergency Medicine
Email: tokarev@neurosklif.ru
ORCID iD: 0000-0002-8415-5602
SPIN 代码: 1608-0630
Scopus 作者 ID: 56559651400
Cand. Sci. (Med.), Neurosurgeon, N.V. Sklifosovsky Research Institute of Emergency Medicine
俄罗斯联邦, MoscowOlga Evdokimova
N.V. Sklifosovsky Research Institute for Emergency Medicine
Email: liveryevna@yandex.ru
ORCID iD: 0000-0001-8099-9544
SPIN 代码: 8357-7392
Scopus 作者 ID: 57212801333
Radiologist, Head, Radiosurgery Center, N.V. Sklifosovsky Research Institute of Emergency Medicine
俄罗斯联邦, MoscowMaria Neznanova
N.V. Sklifosovsky Research Institute for Emergency Medicine
Email: mashaneznanova@inbox.ru
ORCID iD: 0000-0002-0635-6783
SPIN 代码: 3003-1528
Scopus 作者 ID: 57221967771
Radiologist, N.V. Sklifosovsky Research Institute of Emergency Medicine
俄罗斯联邦, MoscowMikhail Sinkin
N.V. Sklifosovsky Research Institute for Emergency Medicine; A.I. Yevdokimov Moscow State University of Medicine and Dentistry
Email: mvsinkin@gmail.com
ORCID iD: 0000-0001-5026-0060
SPIN 代码: 2114-6130
Scopus 作者 ID: 12775157800
D. Sci. (Med.), Senior Researcher, Neurologist, N.V. Sklifosovsky Research Institute of Emergency Medicine; Head, Laboratory of Invasive Neurointerfaces, A.I. Yevdokimov Moscow State University of Medicine and Dentistry
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