Venous thrombogenesis and functional state of the hemorheology and hemostasis system in stroke patients
- 作者: Ryabinkina Y.V.1, Piradov M.A.1, Tanashyan M.M.1, Shabalina A.A.1, Kostyreva M.V.1
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隶属关系:
- Research Center of Neurology
- 期: 卷 10, 编号 1 (2016)
- 页面: 6-13
- 栏目: Original articles
- URL: https://ogarev-online.ru/2075-5473/article/view/124642
- DOI: https://doi.org/10.17816/psaic76
- ID: 124642
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Comparison of the results of investigation of the hemorheology and hemostasis system in patients with stroke of various types, localization, and severity who were treated at critical and intensive care units, with venous thromboembolic complications (VTECs) and without VTEC, demonstrated a high significance of impairments in the hemorheology and hemostasis system for VTEC pathogenesis in stroke patients. Despite ongoing anticoagulant therapy, aggravation of the prothrombogenic state was observed in VTEC patients. Ischemic stroke was associated with more severe changes compared to hemorrhagic stroke. Hemostasiological predictors of VTEC were identified. In patients without VTEC, both the coagulation and anticoagulation systems as well as the fibrinolysis system were preserved. The D-dimer and thrombophilia markers, such as hyperhomocysteinemia and antiphospholipid syndrome, were shown not to contribute to the development of VTEC in stroke patients.
作者简介
Yulia Ryabinkina
Research Center of Neurology
编辑信件的主要联系方式.
Email: ryabinkina11@mail.ru
ORCID iD: 0000-0001-8576-9983
D. Sci. (Med.), Head, Intensive critical care department
俄罗斯联邦, 125367 Moscow, Volokolamskoye shosse, 80Mikhail Piradov
Research Center of Neurology
Email: ryabinkina11@mail.ru
ORCID iD: 0000-0002-6338-0392
D. Sci. (Med.), Professor, Full Member of the Russian Academy of Sciences, Director
俄罗斯联邦, MoscowMarine Tanashyan
Research Center of Neurology
Email: ryabinkina11@mail.ru
ORCID iD: 0000-0002-5883-8119
D. Sci. (Med.), Prof., Corresponding member of RAS, Deputy Director for science, Head, 1st Neurological department
俄罗斯联邦, MoscowAlla Shabalina
Research Center of Neurology
Email: ryabinkina11@mail.ru
ORCID iD: 0000-0001-9604-7775
D. Sci. (Med.), leading researcher, Head, Laboratory of hemorheology, hemostasis and pharmacokinetics (with clinical laboratory diagnostics)
俄罗斯联邦, MoscowM. Kostyreva
Research Center of Neurology
Email: ryabinkina11@mail.ru
俄罗斯联邦, Moscow
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