Methodical recommendations of the ministry of health of the Russian Federation on systemic toxicity of local anesthetic

R. E. Lachin; Лахин Р. Е.; A. Zh. Bayalieva; Баялиева А. Ж.; A. A. Ezhevsky; Ежевская А. А.; D. V. Zabolotsky; Заболотский Д. В.; V. A. Koryachkin; Корячкин В. А.; A. V. Kulikov; Куликов А. В.; A. M. Ovechkin; Овечкин А. М.; D. N. Uvarov; Уваров Д. Н.; G. E. Ulrikh; Ульрих Г. Э.; G. V. Filippovich; Филиппович Г. В.; E. M. Shifman; Шифман Е. М.

doi:10.17816/ра.v13i1-4.43863

Methodical recommendations of the ministry of health of the Russian Federation on systemic toxicity of local anesthetic

作者: Lachin R.E.¹, Bayalieva A.Z.², Ezhevsky A.A.³, Zabolotsky D.V.⁴, Koryachkin V.A.⁴, Kulikov A.V.⁵, Ovechkin A.M.⁶, Uvarov D.N.⁷, Ulrikh G.E.⁴, Filippovich G.V.⁸, Shifman E.M.⁹
隶属关系:
1. Military Medical Academy named after S.M.Kirov of the Ministry of defence of the Russian Federation
2. Kazan State Medical University of the Ministry of health of the Russian Federation
3. Privolzhsky Research Medical University of the Ministry of Health of the Russian Federation
4. St. Petersburg State Pediatric Medical University of the Ministry of Healthcare of the Russian Federation
5. Urals State Medical University of the Ministry of Healthcare of the Russian Federation
6. I.M. Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation (Sechenov University)
7. Northern State Medical University of the Ministry of Healthcare of the Russian Federation,
8. «National Medical Research Center for Obstetrics, Gynecology and Perinatology Named After Academician V.I.Kulakov» of the Ministry of Healthcare of the Russian Federation
9. M.F. Vladimirsky Moscow Regional Research Clinical Institute
期: 卷 13, 编号 1-4 (2019)
页面: 31-41
栏目: Forum
URL: https://ogarev-online.ru/1993-6508/article/view/43863
DOI: https://doi.org/10.17816/ра.v13i1-4.43863
ID: 43863

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Methodological recommendations of the Ministry of health of the Russian Federation “Systemic toxicity of local anesthetics” were prepared by the all-Russian public organization “Federation of anesthesiologists and resuscitators”. Systemic toxicity of local anesthetics is a rare but dangerous complication of regional anesthesia. These recommendations provide updated indicators of the prevalence of this complication, the preventive value of ultrasound navigation, and the evolution of the clinical picture. The results of the analysis of new reports indicate a trend towards delayed manifestation of symptoms after regional anesthesia. The type of local anesthetic, dosage, volume, injection site, and concomitant diseases of the patient affect the rate of absorption from the injection site and the toxicity of local anesthetics. The article presents new information about the mechanisms of lipid resuscitation, summarizes the latest scientific data on the mechanisms of neutralization of local anesthetics in blood plasma by introducing fat emulsions, including the effect of rapid redistribution, direct inotropic effect and postconditioning. Guidelines for the prevention, recognition and treatment of systemic toxicity of local anesthetics have been updated in accordance with new data.

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local anesthetic, systemic toxicity, lipid emulsion, lipid resuscitation, regional anesthesia

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作者简介

R. Lachin

Military Medical Academy named after S.M.Kirov of the Ministry of defence of the Russian Federation

编辑信件的主要联系方式.
Email: doctor-lahin@yandex.ru
ORCID iD: 0000-0001-6819-9691

Dr. Med. Sci., Docent, Professor, Department of Anesthesiology and Intensive Care

俄罗斯联邦, 194044, Saint Petersburg

参考

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Neal J.M., Woodward C.M., Harrison T.K. The American Society of Regional Anesthesia and Pain Medicine Checklist for Managing Local Anesthetic Systemic Toxicity: 2017 Version. Reg. Anesth. Pain. Med. 2018; 43 (2): 150−3. doi: 10.1097/AAP.0000000000000726.
The Association of Anaesthetists of Great Britain & Ireland. Guidelines for the Management of Severe Local Anaesthetic Toxicity. Available at: http://aagbi.org/sites/default/files/la_toxicity_2010_0.pdf. doi: 10.21466/g.MOSLAT2.2010
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Methodical recommendations of the ministry of health of the Russian Federation on systemic toxicity of local anesthetic

全文:

详细

关键词

全文:

作者简介

R. Lachin

A. Bayalieva

A. Ezhevsky

D. Zabolotsky

V. Koryachkin

A. Kulikov

A. Ovechkin

D. Uvarov

G. Ulrikh

G. Filippovich

E. Shifman

参考

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