Calculation of Na+/Cl Selectivity in Tight Junctions between Epithelial Cells by Methods of Nonlocal Electrostatics with Pole Models of Dielectric Function without an Overscreening Effect


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A mathematical model of Na+/Cl selectivity in tight junctions (TJs) between epithelial cells was developed. It was demonstrated that Na+/Cl selectivity in TJs depends on the total charge of amino-acid residues of claudin macromolecules within TJs, as well as on the ion-distribution coefficients between TJs and free solution. It was demonstrated that the obtained formulas predict a change of Na+/Cl selectivity in TJs for Cl/Na+ selectivity if the sign of the total charge of amino-acid residues in TJ changes. The calculated Na+/Cl selectivity value for MDCK cells coincides with the experimental data of (Colegio et al., 2002). To calculate a change in ion-solvation energy during their transition to TJs, formulas for nonlocal electrostatics with one-, two-, and three-pole models of dielectric function without taking into account the overscreening effect were used.

作者简介

A. Rubashkin

Institute of Cytology

编辑信件的主要联系方式.
Email: andrey.rubashkin@gmail.com
俄罗斯联邦, St. Petersburg, 194064

P. Iserovich

Downstate Medical Center

Email: andrey.rubashkin@gmail.com
美国, New York, 11203

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