The Effect of Noopept on Neurochemical Changes in the Retina during the Experimental Thrombosis of Its Vessels
- 作者: Kolesnikov A.V.1, Shchul’kin A.V.1, Barenina O.I.1, Yakusheva E.N.1, Kudrin V.S.2, Ostrovskaya R.U.2, Uzbekov M.G.3, Shishkin M.M.4
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隶属关系:
- Ryazan State Medical University
- Zakusov Institute of Pharmacology
- Moscow Institute of Psychiatry
- Pirogov National Medical Surgery Center
- 期: 卷 13, 编号 1 (2019)
- 页面: 62-67
- 栏目: Experimental Articles
- URL: https://ogarev-online.ru/1819-7124/article/view/211647
- DOI: https://doi.org/10.1134/S1819712419010112
- ID: 211647
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详细
We studied the effect of the neuroprotective dipeptide drug noopept on the level of biogenic amines in the retina during the thrombosis of its vessels in experiments with male chinchilla rabbits. Ischemic lesion of the retina was modeled by intravenous administration of rose bengal at a dose of 40 mg/kg body weight followed by 10-min transpupillary focal illumination of the temporal vascular arcade with white light. Noopept was injected intravenously immediately after the thrombosis modeling at a dose of 0.5 mg/kg body weight; then, throughout the entire experiment (up to 14 days) it was administered per os three times a day at a dose of 10 mg/kg body weight. It has been demonstrated that ischemia causes the following disturbances in the neurotransmitter balance in the retina: an increase in the aspartate and GABA levels, a decrease in the dopamine and taurine levels, and a decrease followed by an increase in the glycine level. Noopept administration led to the normalization of the GABA, glycine, and aspartate levels and an increase in the dopamine content.
作者简介
A. Kolesnikov
Ryazan State Medical University
Email: alekseyshulkin@rambler.ru
俄罗斯联邦, Ryazan
A. Shchul’kin
Ryazan State Medical University
编辑信件的主要联系方式.
Email: alekseyshulkin@rambler.ru
俄罗斯联邦, Ryazan
O. Barenina
Ryazan State Medical University
Email: alekseyshulkin@rambler.ru
俄罗斯联邦, Ryazan
E. Yakusheva
Ryazan State Medical University
Email: alekseyshulkin@rambler.ru
俄罗斯联邦, Ryazan
V. Kudrin
Zakusov Institute of Pharmacology
Email: alekseyshulkin@rambler.ru
俄罗斯联邦, Moscow
R. Ostrovskaya
Zakusov Institute of Pharmacology
Email: alekseyshulkin@rambler.ru
俄罗斯联邦, Moscow
M. Uzbekov
Moscow Institute of Psychiatry
Email: alekseyshulkin@rambler.ru
俄罗斯联邦, Moscow
M. Shishkin
Pirogov National Medical Surgery Center
Email: alekseyshulkin@rambler.ru
俄罗斯联邦, Moscow
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