Neuro-microglial interactions in the spinal centers of pain modulation in the neuropathic pain syndrome


如何引用文章

全文:

开放存取 开放存取
受限制的访问 ##reader.subscriptionAccessGranted##
受限制的访问 订阅存取

详细

The dynamics of the expression of the neuronal NO-synthase and microglia activity in the spinal centers of pain modulation were studied on the ligated rat sciatic nerve. The development of neuropathic pain causes an increase in the activity of neuronal NO-synthase and the iba-1-positive microglia in the spinal ganglia and the surface laminae of the posterior horn of the spinal cord, which dynamically corresponds to the severity of pain. At the same time, the dynamics of NO-ergic activity are parallel with the activation of microglia in these brain structures. Thus, we cannot exclude the direct inter-modulating effects of spinal microglia and NO-ergic nociceptive neurons.

作者简介

I. Manzhulo

A.V. Zhirmunsky Institute of Marine Biology, Far Eastern Branch; School of Biomedicine; Aff3

编辑信件的主要联系方式.
Email: i-manzhulo@bk.ru
俄罗斯联邦, Vladivostok; Vladivostok; ul. Palchevskogo 17, Vladivostok, 690041

O. Ogurtsova

A.V. Zhirmunsky Institute of Marine Biology, Far Eastern Branch

Email: i-manzhulo@bk.ru
俄罗斯联邦, Vladivostok

A. Tyrtyshnaia

A.V. Zhirmunsky Institute of Marine Biology, Far Eastern Branch; School of Biomedicine

Email: i-manzhulo@bk.ru
俄罗斯联邦, Vladivostok; Vladivostok

I. Dyuizen

A.V. Zhirmunsky Institute of Marine Biology, Far Eastern Branch

Email: i-manzhulo@bk.ru
俄罗斯联邦, Vladivostok

补充文件

附件文件
动作
1. JATS XML

版权所有 © Pleiades Publishing, Ltd., 2017