Suppression of adult hippocampal neurogenesis due to Wnt3a lentivirus transduction


如何引用文章

全文:

开放存取 开放存取
受限制的访问 ##reader.subscriptionAccessGranted##
受限制的访问 订阅存取

详细

The aim of our study was to investigate the effect of lentivirus-induced Wnt3a overexpression in the dentate gyrus of the hippocampus on the intensity of neurogenesis in this neurogenic zone of adult rats. Virus transduction resulting in local overproduction of Wnt3a was accompanied by a significant decrease in the density of doublecortin-positive cells in the transfected area. This may reflect the suppression of neuronal differentiation of cells generated in the hippocampus during adult neurogenesis. This effect was limited to the region of local overproduction of Wnt3a. A decreased level of doublecortin was not associated with any degenerative alterations in the dentate-gyrus tissue.

作者简介

V. Aniol

Laboratory of the Functional Biochemistry of the Nervous System, Institute of Higher Nervous Activity and Neurophysiology; Aff3

编辑信件的主要联系方式.
Email: aniviktor@narod.ru
俄罗斯联邦, Moscow; ul. Butlerova 5a, Moscow, 117485

A. Tishkina

Laboratory of the Functional Biochemistry of the Nervous System, Institute of Higher Nervous Activity and Neurophysiology

Email: aniviktor@narod.ru
俄罗斯联邦, Moscow

S. Salozhin

Laboratory of Molecular Neurobiology, Institute of Higher Nervous Activity and Neurophysiology

Email: aniviktor@narod.ru
俄罗斯联邦, Moscow

A. Kvichanskii

Laboratory of the Functional Biochemistry of the Nervous System, Institute of Higher Nervous Activity and Neurophysiology

Email: aniviktor@narod.ru
俄罗斯联邦, Moscow

N. Gulyaeva

Laboratory of the Functional Biochemistry of the Nervous System, Institute of Higher Nervous Activity and Neurophysiology

Email: aniviktor@narod.ru
俄罗斯联邦, Moscow

补充文件

附件文件
动作
1. JATS XML

版权所有 © Pleiades Publishing, Ltd., 2016