Modeling of Alzheimer’s Disease and Outlooks for its Therapy Using Induced Pluripotent Stem Cells

Resumo

Abstract—Development of the technology of induced pluripotent stem cells (iPSC) opened new opportunities for studies of the mechanisms of pathogenesis and effective treatment of acute and chronic forms of cerebral pathologies. Here, we review current literature data on the use of the iPSC technology for in vitro modeling of Alzheimer’s disease, search for new pharmacological drugs for its treatment, and modern approaches to neurotransplantation for personalized cellular therapy.