Markers of structural and functional impairments of the central nervous system in an experimental model of thiopental coma


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The markers of impairments of the nervous system were evaluated in rats at various time points after a sodium thiopental injection at the LD50 using biochemical and immunohistochemical methods. The thiopental coma state was associated with a decrease in the levels of superoxide dismutase 6 h after the injection, glucose-6-phosphate dehydrogenase 24 and 72 h after the injection, and pigment epithelium-derived factor 6᾿2 h after the injection, as well an increase in the levels of glutathione peroxidase 72 h after the injection and caspase-3 6 h after the injection in the blood plasma of rats. Immunohistochemical study of caspase-3 in the brain tissue revealed increased expression of the enzyme in the sensorimotor cortex and hippocampus 3 days after the thiopental injection.

Sobre autores

A. Shvetsov

Institute of Toxicology; Aff2

Autor responsável pela correspondência
Email: shvetsov83@mail.ru
Rússia, St. Petersburg; Bekhtereva, 1, St. Petersburg, 129019

E. Batotsyrenova

Institute of Toxicology

Email: shvetsov83@mail.ru
Rússia, St. Petersburg

S. Stepanov

Institute of Toxicology

Email: shvetsov83@mail.ru
Rússia, St. Petersburg

M. Ivanov

Institute of Toxicology

Email: shvetsov83@mail.ru
Rússia, St. Petersburg

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